Introduction: The relation between morphine and nitric oxide release has been shown. Due to important role of nitric oxide in regulation of skin blood flow, the aim of this study was to investigate the effect of nitric oxide synthase inhibitor (L-NAME) and nitric oxide synthesis precursor (L-arginine) on skin blood flow of intact and morphine-dependent rats. Methods: Skin blood flow of hind pa...

A transient ipsilateral retinotectal projection is normally eliminated during embryonic development of the chick visual system. Administration of the NMDA receptor antagonist 5-methyl-10, 11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine (MK-801) during the developmental period in which this projection normally disappears prevented its complete elimination. Previous studies showed that tectal ce...

background: the aim of this study was to compare the effects of diode laser irradiation on wound healing in oral rat mucosa and also to measure the amount of inducible nitric oxide synthase (inos) and endothelial nos (enos) on oral wound healing. healing was assessed by histology and the amounts of enos and inos were measured by real‑time polymerase chain reaction (pcr). materials and methods: ...

the genus artemisia is estimated to comprise over 800 species with anti-cancer, anti-fungal, anti-oxidant and anti-inflammatory properties. artemisia fragrans ( a. fragrans ), a species that belongs to genus artemisia , is rich in monoterpenes and sesquiterpenes derivatives. due to anti-inflammatory properties of monoterpenes and sesquiterpenes, we aimed to investigate the effect of a. fragrans...

Objective(s):Some pathologic situations such as diabetes and metabolic syndrome are associated with alternation in nitric oxide level. Incidence of these condition increases with aging. On the other hand, insulin secretion is modulated by nitric oxide, and nitric oxide synthase (NOS) activity is also altered in diabetes. In this study, modification in the enzyme activity associated with aging a...

eNOS: endothelial nitric oxide synthase Hcy: homocysteine NO: nitric oxide VEGF: vascular endothelial growth factor INTRODUCTION This report shows a positive therapeutic effect of high-dose folic acid plus vitamins B6 and B12 on a patient with palmar plantar pustulosis. Improvement was likely through modulation of homocysteine (Hcy) and nitric oxide (NO) synthase metabolic pathways, and by inhi...

Hypertension IS accompanied by architectural changes m the kidney, heart, and vessels that are often maladaptlve and can eventually contribute to end-organ disease such as renal failure, heart failure, and coronary disease Nitric oxide, an endogenous vasodllator and antlthrombotlc agent synthesized m the endothehum by a constltutlve mtnc oxide synthase, mhlblts growth-related responses to injur...