Murexide, a reddish purple compound has the structure shown in Fig. 1. It has received much interest because of its application in chemical analysis and spectrophotometric fields [1, 2]. It is considered as the ammonium salt of purpuric acid and named as ammonium 2,6-dioxo-5-(2,4,6-trioxo-tetrahydro-pyrimidine-5-ylidene amino)-1,2,3,6-tetrahydro-pyrimidine-4-olate. It serves as a metal ion indi...

Because betel quid chewing has been linked to the development of oral cancer, pathobiological effects of an aqueous areca nut extract, four areca nut alkaloids (arecoline, guvacoline, guvacine, and arecaidine), and four nitrosated derivatives [N-nitrosoguvacoline, N-nitrosoguvacine, 3-(N-nitrosomethylamino)propionaldehyde and 3-(N-nitrosomethylamino)propionitrile] have been investigated using c...

N-nitrosamines are a class of carcinogenic chemical compound. Considering the large-scale application agrochemicals globally, elimination from pesticides should be priority for manufacturers and regulators. A set methods was developed validated determination toxicologically relevant N-nitrosamine impurity ethalfluralin (ethyl-N-(2-methylallyl) N-nitroso amine—EMANA) in 33% w v−1 emulsifiable co...

An objective of this work was to assess the biological activity of beetroot juice (Chrobry variety, Beta vulgaris L. ssp. vulgaris), which was lactofermented by probiotic bacteria Lactobacillus brevis 0944 and Lactobacillus paracasei 0920. The oxidative status of blood serum, kidneys, and liver of rats consuming the fermented beetroot juice were determined. The experimental rats were divided in...

O6-Butylguanine was detected in the urine of rats given the butylating agent N-nitroso-N-butylurea. O6-Butylguanine contents in the 24-h rat urine samples after i.p. doses of 50, 100, and 200 mg/kg N-nitroso-N-butylurea were 1.03 +/- 0.41 (SE), 8.30 +/- 1.70, and 59.53 +/- 6.52 pmol, respectively. This suggests that O6-butylguanine formation in nucleic acids might be repaired in vivo, possibly ...

Nutrition and the fmmation of N-nitroso compounds N-nitroso compounds are an important group of chemical carcinogens that could be involved in human cancer (Magee, 1982). Only a few examples have been found in food and beverages (Assembly of Life Sciences, 1981) but suitable precursors are common dietary constituents (Assembly of Life Sciences, 1981), and the mildly acidic conditions of the sto...

A N-nitroso moiety can be used for the activation of chloropyrimidines toward a nucleophilic substitution reaction with amines. The subsequent treatment of the obtained products with aq H2SO4 can lead to either N-denitrosation to obtain 4,6-pyrimidinediamines or to a Fischer-Hepp type rearrangement to obtain 5-nitroso-4,6-pyrimidinediamines. It was found that the outcome of the reaction strongl...

Research focused on preparing new type curing pigment, which called Nitroso-hemoglobin prepared by use of by-products (beef blood), and its application prospect substitutes of nitrite, because of its a poisonous reagent, and can produce carcinogenic nitrosamine after reacting with amine and lead to carcinogenicity, nitrosamines toxicity in meet's product, and this project defined the developmen...

Several possible risk factors for brain tumors have been suggested in the past, including N-nitroso compounds, but with the exception of ionizing radiation, none has been consistently confirmed. The present study was aimed at assessing the influence of nutritional factors, including N-nitroso compounds, in the etiology of brain tumors, specifically gliomas and meningiomas. One hundred and thirt...

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