Special diets that were extremely low in protein (5.5%) and high in carbohydrate were used to test the effect of nicotinamide on A/-nitrosodimethylamine-induced Carcinogenesis in Holtzman albino rats. The level of nicotinamide in the three diets ranged from 0 mg/kg of food to 50 mg/kg to 500 mg/kg. During the treatment with these diets (5 weeks) and the carcinogen (18 days), the renal and hepat...

Since the detection of N-nitrosodimethylamine (NDMA) in a batch valsartan 2018, at levels exceeding ICH acceptable intake limits for mutagenic impurities, analysis nitrosamines has become an intense focus point pharmaceutical industry. The identification and low-level determination potentially affected materials is challenging requires application highly sensitive analytical techniques. This ar...

./V-acetoxy-acetylaminofluorene; but no increase was demon strated when cells were treated with ./V-nitrosodiethylamine, yV-nitrosodimethylamine, or 2-acetylaminofluorene. The frequency of viral transformation increased linearly with chemical concentration until a maximum level was reached; however, higher concentrations decreased the trans formation frequency relative to that observed with low...