Peripheral T-cell lymphomas are a group of heterogeneous disorders and according to WHO classification, are categorized into nodal and extranodal forms. NK/T-cell lymphoma, nasal type, is a subtype of extranodal peripheral T-cell lymphoma and commonly presents as a midfacial destructive lesion. This disorder is more prevalent in Asia and South America and has a strong association with Epstein B...

background: perforin is known to be important in cytolytic activity mediated by natural killer (nk) cells.   objective: to study the relationship between the efficiency of nk and lymphokine-activated killer (lak) cells activity, and the expression of perforin and hla class i molecules.   methods: lak cells were generated by in vitro culturing of human peripheral blood lymphocytes (pbls) in the ...

background: natural killer (nk) cells are the effector cells of innate immunity that respond to infection and tumor. interactions between killer cell immunoglobulin like receptors (kir) and human leukocyte antigen (hla) class i molecules regulate nk cells responses to eliminate infected and transformed cells. objective: to investigate the impact of kir genes, hla ligand genes, and kir-hla combi...

Background: NK (natural killer) and NKT (natural killer T) cells, as components of innate immune system, play a crucial role in tumor progression and dissemination. Objective: To investigate the percentages of NK cells, NKT cells, iNKT (invariant natural killer T) cells, total T lymphocytes as well as activated T lymphocytes, in tumor draining lymph nodes (TDLN...

The objective of this paper is to examine the asymptotic behavior persistence diagrams associated with Čech filtration. A diagram a graphical descriptor topological and algebraic structure geometric objects. We consider filtration over scaled random sample rn−1Xn={rn−1X1,…,rn−1Xn}, such that rn→0 as n→∞. treat point process establish their limit theorems in sparse regime: nrnd→0, In setting, we...

Una de las herramientas más novedosas en inmunoterapias adoptivas contra leucemias y tumores malignos es el uso del receptor antígeno quimérico “CAR”. El CAR ha sido ampliamente utilizada células T (células CAR-T) potenciando su eficacia reconocimiento eliminación tumores, obteniéndose a la fecha terapias basadas esta tecnología. No obstante, CAR-T llegan repercutir negativamente salud paciente...