Main results People receiving sertraline maintenance had better psychosocial outcomes compared to placebo (table). Depression recurrence was 6% with sertraline and 23% with placebo maintenance (NNT 6, 95% CI 4 to 15; relative risk reduction 74%, 95% CI 49% to 99%). Symptom re-emergence was 26% with sertraline versus 50% with placebo (NNT 4, 95% CI 3 to 11, relative risk reduction 48%, 95% CI 25...

It is by no means straightforward to analyse the change in the rate of chronic obstructive pulmonary disease (COPD) exacerbations in clinical trials. Exacerbation rates do not follow a normal distribution, nor do they occur at random. High exacerbation rates in a few patients can make average rates difficult to calculate and interpret. So, surely, transforming exacerbation rates into numbers ne...

In this paper an ARIMA model is used for time-series forecast involving wind speed measurements. Results are compared with the performance of a back propagation type NNT. Results show that ARIMA model is better than NNT for short time-intervals to forecast (10 minutes, 1 hour, 2 hours and 4 hours). Data was acquired from a unit located in Southern Andalusia (Peñaflor, Sevilla), with a soft orog...

The number needed to treat (NNT) is becoming increasingly popular as an index for reporting the results of randomized trials and other clinical studies. It represents the expected number of patients who must be treated with an experimental therapy in order to prevent one additional adverse outcome event (or, depending on the context, to expect one additional beneficial outcome), compared to the...

Background Several recent trials in chronic obstructive pulmonary disease (COPD) have assessed the effectiveness of fluticasone–salmeterol combination inhaler preventing COPD exacerbations, while finding an increased risk pneumonia. The number needed to treat (NNT) is a simple measure perform comparative benefit–risk impact, but its calculation involving repeated outcome events such as...

Although nicotinamide nucleotide transhydrogenase (NNT)-deficient C57BL/6J (6J) mice are known to be highly susceptible to diet-induced metabolic disease, this notion stems primarily from comparisons of 6J mice to other inbred strains. To date, very few studies have directly compared metabolic disease susceptibility between NNT-deficient 6J mice and NNT-competent C57BL/6 substrains. In this stu...

OBJECTIVE Comparison of the efficacy and tolerability of five newer anti-obesity medications to guide clinical decision making, examining bupropion-naltrexone combination, liraglutide, lorcaserin, orlistat, and phentermine-topiramate combination. METHODS A brief literature review and internet search for high-powered, randomized and placebo-controlled drug trials was conducted. Drug trial info...

BACKGROUND Previous studies have identified various risk factors for neonatal tetanus (NNT) in rural areas of Pakistan. The present matched case control study was conducted to further evaluate these risk factors in an urban setting. AIM The study was carried out to identify risk factors for NNT in Karachi. MATERIALS AND METHODS Patients of NNT (n = 125) diagnosed from January 1998 to Februa...

Purpose: Several studies have reported a positive impact for taxanes in adjuvant breast cancer (BC) treatment in terms of reduced recurrence and mortality. However the impact of the magnitude on overall survival (OS) remains partially controversial. Methods: We examined the impact of taxane-containing adjuvant therapy for patients with early BC on OS, based on the number of deaths and on the ca...