Medication adherence usually refers to whether patients take their medications as prescribed (eg, twice daily), as well as whether they continue to take a prescribed medication. Medication nonadherence is a growing concern to clinicians, healthcare systems, and other stakeholders (eg, payers) because of mounting evidence that it is prevalent and associated with adverse outcomes and higher costs...

Medication Adherence and Psychoeducation Despite the effectiveness of psychopharmocological interventions in producing improved outcomes in schizophrenia, medication nonadherence occurs frequently (in up to 50% or more of cases) and for various reasons (123). A recent comprehensive review identified that the lack of awareness of illness was a key factor in medication nonadherence (124). Such la...

BACKGROUND Inhibitors of BRAF and the downstream signaling protein MEK have improved outcomes for patients with BRAF-mutant advanced malignant melanoma. Despite their ease of administration, these oral therapies pose adherence challenges. 
. OBJECTIVES This article aims to increase awareness of causes of nonadherence to oral targeted therapies in advanced malignant melanoma and to provide onc...

Asthma is one of the most common chronic inflammatory disorders in children. Nonadherence to medical therapy is a major cause of poor clinical outcome the objective of this study was evaluating factors, which are resulted in nonadherence to medical therapy in children with asthma.In this descriptive study, 150 children with asthma and nonadherent to medication therapy were enrolled. General inf...

BACKGROUND Intravenous thrombolysis (IVT) for acute ischemic stroke is subject to label and guideline contraindications. Updated European guidelines in 2008/2009 recommended IVT in selected patients aged >80 years and stroke onset-to-treatment time 3 to 4.5 hours, which the label still prohibited. Our aim was to compare contraindication nonadherence before and after the guideline update. METH...

BACKGROUND Depression leads to adverse outcomes in patients with coronary heart disease (CHD). Medication nonadherence is a potential mechanism for the increased risk of CHD events associated with depression, but it is not known whether depression is associated with medication nonadherence in outpatients with stable CHD. METHODS We examined the association between current major depression (as...

Heparinized samples of blood from three different patients were coded by impartial observers. The buffy coat leukocytes from the coded samples of blood were isolated and incubated separately with extracts of colon and pancreatic cancer in the tube leukocyte adherence inhibition assay. At the completion of the assay, the leukocytes from Patient 1 were equally nonadherent to both cancer extracts ...

PURPOSE There is strong evidence supporting the link between nonadherence to antipsychotic medication and relapse of schizophrenia. However, less obvious are the economic consequences of nonadherence. The systematic review reported here evaluated the economic aspects of nonadherence to antipsychotic medication. METHODS A systematic review of scientific papers in the PubMed MEDLINE, Embase, Ps...

Medications play a prominent role in the treatment of many illnesses. Failing to adhere to prescribed medication regimens contributes to an array of poor health outcomes. In addition to the cost in terms of human suffering, the financial cost of medication nonadherence is staggering. Poor health literacy has been identified as a major cause of medication nonadherence. This paper focuses on nona...