Background and objectivesLiver damage in cholestasis is multifactorial, yet bile acid-mediated hepatotoxicity pivotal. Honey consumption has many physiological effects; it influences detoxification process (phase I, II III), antioxidant, anti-inflammatory, immune-stimulant, anti-ulcer, wound/burn healing effects others. The acid ursodeoxycholic (UDCA) currently used off-label to treat neonatal ...

A consensus needs to be reached on a rational approach to infertile men with varicocele-associated nonobstructive azoospermia. Future studies are warranted to understand the mechanism behind the variable influence of varicocele on testicular function, which causes partial or complete damage of spermatogenesis in some cases and leaves it unaltered in others.

BACKGROUND In hypertrophic cardiomyopathy (HCM), heart transplant has been predominantly confined to patients with systolic dysfunction. An underappreciated HCM subset comprises patients with preserved left ventricular (LV) systolic function who may also require consideration for transplantation. Therefore, we sought to define the clinical profile and occurrence of advanced heart failure among ...

OBJECTIVE The objective of this study was to determine the safety and efficacy of sacral neuromodulation (SNM) in patients with idiopathic nonobstructive urinary retention. MATERIALS AND METHODS We retrospectively reviewed the files of patients who underwent staged neuromodulation for idiopathic nonobstructive urinary retention from 2004 to 2016 at our hospital. Patients who had a 50% improve...

BACKGROUND The objective of this study was to assess the efficacy of sealing intermediate nonobstructive coronary saphenous vein graft (SVG) lesions with drug-eluting stents (DES; paclitaxel- or everolimus-eluting stents) for reducing major adverse cardiac events (MACE). METHODS AND RESULTS This was a randomized controlled multicenter clinical trial that enrolled patients with a previous coro...

BACKGROUND Computed tomography-adapted Leaman score (CT-LeSc) was developed to quantify coronary CT angiography information about atherosclerotic burden (lesion localization, stenosis degree, and plaque composition). The objective of the study is to evaluate CT-LeSc long-term prognostic value in patients with suspected coronary artery disease (CAD). METHODS AND RESULTS Single-center prospecti...

Extramedullary plasmacytoma is a rare cause of nonobstructive colonic masses, which is often disregarded. Plasmacytoma is a neoplastic proliferation of plasma cells; when systemic involvement occurs, the disease is named multiple myeloma. Extramedullary plasmacytomas comprise 4% of all plasma cell tumours and occur mainly in the upper respiratory tract; gastrointestinal system involvement is ra...

A n 85-year-old man with a 4-day history of generalized fatigue presented at our emergency department with worsening symptoms of fatigue and dyspnea. Electrocardiography revealed a junctional escape rhythm at a rate of approximately 50 beats/min and ST-segment elevations in the inferior leads and in V4R. Coronary angiography revealed proximal occlusion of the right coronary artery and nonobstru...