In flaviviruses it has been proposed that there is a coupling between genome replication and virion assembly and that nonstructural proteins are involved in this process. It was previously reported that mutations in yellow fever virus (YFV) nonstructural protein NS2A blocked production of infectious virus and that this block could be released by a suppressor mutation in NS3. Here, based on stud...

Hepatitis C virus infection is causing chronic liver disease, cirrhosis, and hepatocellular carcinoma. By combining direct-acting antivirals (DAAs), high sustained virologic response rates (SVRs) can be achieved. Resistance-associated substitutions (RASs) are commonly observed after DAA failure, especially nonstructural protein 5A (NS5A) RASs may impact retreatment options.1–3 Data on of failur...

GI disorders affect the quality of children. Children with Down syndrome have a high prevalence disorders. This study aims to determine life children is cross-sectional using PedsQL Symptoms Scale questionnaire & ROME IV Diagnostic Questionnaire for Pediatric Functional Gastrointestinal Disorder Adolescents. Samples were collected in January-May 2022. The analysis was performed IBM SPSS Sta...

Abstract Background Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the etiologic agent of coronavirus disease 2019 (COVID-19), is rapidly acquiring new mutations. Analysis these mutations necessary for gaining knowledge regarding different aspects therapeutic development. Previously, we have reported a Sanger method-based genome sequence viral isolate named SARS-CoV-2 NIB-1, circ...