Recessive dystrophic epidermolysis bullosa, a genodermatosis characterized by dermolytic blister formation in response to minor trauma, is characterized by an incresaed collagenase synthesis by skin fibroblasts in culture. Since preliminary studies of partially purified recessive dystrophic epidermolysis bullosa collagenase suggested that the protein itself was aberrant, efforts were made to pu...

conclusions since telomerase is expressed in 90% of cancer cells, its inhibition can be considered as a goal of cancer treatment. results about 90% of cancers need a high level of this enzyme to continue cell multiplication. since this enzyme set is absent in normal cells, or present at a very low level, use of telomerase inhibitors cannot have significant effects on normal cells. evidence acqu...

background: coronary artery disease (cad) is emerging as a major public health concern in most developing countries. during the past 10 years, the vast majority of over 100 case-control retrospective studies have shown that elevated plasma homocysteine level is a strong independent risk factor for coronary artery disease. methylenetetrahydrofolate reductase (mthfr) is a key enzyme in folate and...

Background: The witches’ broom disease of lime caused by <span style="font-variant: normal; font-style: normal; font-family: Capitolium...

Different clinical expressions of acid alpha-glucosidase deficiency have been described. The present study was undertaken to investigate the basic metabolic defect in the infantile and adult forms of the disease. Acid alpha-glucosidase (EC 3.2.1.20) was purified from normal and from adult acid alpha-glucosidase deficiency fibroblasts. The pH optimum; Michaelis constant; electrophoretic mobility...

We have studied the catalytic, immunochemical, and electrophoretic properties of adenine phosphoribosyltransferase in hemolysates from 30 patients with a deficiency of this enzyme in six unrelated families. We have found that: 1) the level of adenine phosphoribosyltransferase enzyme activity and immunoreactive protein in the four homozygous deficient patients was less than 1% of control values;...

Abstract Cigarette smoke contains carcinogenic residues such as volatile organic compounds and polycyclic aromatic hydrocarbons that stay on surfaces can be released into the air causing stains unpleasant smells. The use of chemical cleaners deodorizers may cause other health environmental consequences. Eco-enzyme from waste fruit peels vegetables left over are one innovations commonly used to ...