Background Pediatric nephrolithiasis is a condition the prevalence of which varies geographically with multiple etiologies. The aim of this study was to determine possible concomitant anatomic and metabolic disturbances in children with nephrolithiasis and to answer the questions regarding the role of each metabolic and anatomic abnormality. Materials and Methods Between 2007 and 2015, 1,080 pa...

congenital cutis laxa is an exceptional condition. no large scale pedigree has been reported from iran. we report a family with 106 members with two members affected with cutis laxa. our cases were two patients (male and female) with pre- and postnatal growth retardation, cutis laxa, characteristic facies and other manifestations which proved that they were affected with cutis laxa. their famil...

female fertility begins to decline many years prior to the onset of menopause despite continued regular ovulatory cycles. age related infertility is due to oocyte abnormalities and decreased ovarian reserve. treatment of infertility when the cause is limited to decreased ovarian reserve is empirical at present except for oocyte donation. this mini review of the literature covers all available e...

introduction: many epidemiological studies have been conducted to determine the prevalence of the various types of the dental anomalies. the aim of the present study was determination of developmental and acquired dental anomalies in patients attending the faculty of dentistry in rasht, iran. materials and methods: in this retrospective cross-sectional study, 1224 digital panoramic ra-diographs...

DNA double-strand breaks (DSBs) are among the most deleterious forms of DNA lesions in cells. Here we induced site-specific DSBs in yeast cells and monitored chromatin dynamics surrounding the DSB using Chromosome Conformation Capture (3C). We find that formation of a DSB within G1 cells is not sufficient to alter chromosome dynamics. However, DSBs formed within an asynchronous cell population ...

Laminopathies, mainly caused by mutations in the LMNA gene, are a group of inherited diseases with a highly variable penetrance; i.e., the disease spectrum in persons with identical LMNA mutations range from symptom-free conditions to severe cardiomyopathy and progeria, leading to early death. LMNA mutations cause nuclear abnormalities and cellular fragility in response to cellular mechanical s...

Abstract Funding Acknowledgements Type of funding sources: None. Background Elevated EFV has been recently reported to be prevalent and a possible contributor higher cardiovascular morbidity mortality, particularly in the presence elevated CACS. Purpose To assess whether CACS significant effects on cardiac electrical activity as evidenced by 12-lead ECG abnormalities, addition triggering inflam...

background: the implications of cardiac risk stratification before orthotopic liver transplantation (olt) are not well established. we studied the usefulness of myocardial perfusion imaging (mpi) in this scenario. methods: mpi data of 24 patients (9 females), candidates of olt, were collected. they underwent mpi as part of their preoperative risk assessment. mpis were interpreted by 2 nuclear p...