personalized medicine is significantly changing the fundamentals of healthcare. genetic diagnostic tests are used in various parts of medicine – from initial screening to the diagnosis and finally treatment. investigations in fields of drug development indicate that oncology may lead other therapeutic areas in the number of targeted therapies on the marketplace as well as in the pipeline, expec...

†Background Productive agriculture needs a large amount of expensive nitrogenous fertilizers. Improving nitrogen use efficiency (NUE) of crop plants is thus of key importance. NUE definitions differ depending on whether plants are cultivated to produce biomass or grain yields. However, for most plant species, NUE mainly depends on how plants extract inorganic nitrogen from the soil, assimilate ...

Nutritional genomics has exploded in the last decade, yielding insights-both nutrigenomic and nutrigenetic-into the physiology of dietary interactions and our genes. Among these are insights into the regulation of magnesium transport and homeostasis and mechanisms underlying magnesium's role in insulin and glucose handling. Recent observational evidence has attempted to examine some promising r...

1 Laboratory of Molecular Biology of Exercise, School of Applied Sciences, University of Campinas, Limeira, Brazil, Department of Health Science, Federal University of Lavras, Lavras, Brazil, 3 School of Physical Education and Sport of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil, 4 Laboratory of Nutritional Genomics, School of Applied Sciences, University of Campinas, Limeir...

The narrow genetic basis of many crops combined with restrictions on the commercial use of genetically modified plants, has led to a surge of interest in exploring natural biodiversity as a source of novel alleles to improve the productivity, adaptation, quality and nutritional value of crops. Genetic methodologies have been applied to natural variation to improve quality aspects that are assoc...

In this paper, we study how to automatically extract and visualize food (or nutrition) and disease relationships from Chinese publications of Nutritional Genomics. Different from previous approaches that mostly apply handcrafted rules or co-occurrence patterns, we propose an approach using probabilistic models and domain knowledge. In particular, we first utilize encyclopedia to construct a dom...

Food plays an important role in regulating the various processes within the body. With the continued progression of the “omics” era, bioinformatics curates and interprets biological data by computational means and therefore it has seen widespread integration across every discipline of life sciences including food sciences. Bioinformatics can be used for efficiently access to all genomics, prote...

Maize is an important crop for food, feed, forage, and fuel across tropical and temperate areas of the world. Diversity studies at genetic, molecular, and functional levels have revealed that, tropical maize germplasm, landraces, and wild relatives harbor a significantly wider range of genetic variation. Among all types of markers, SNP markers are increasingly the marker-of-choice for all genom...

Abstract Aspergillus oryzae ( A. ) is a filamentous micro-fungus that used from centuries in fermentation of different foods many countries all over the world. This valuable fungus also rich source bioactive secondary metabolites. Moreover, has prestigious secretory system allows it to secrete high concentrations proteins into its culturing medium, which support use as biotechnological tool vet...