background: this study aimed to assess the effectiveness of topiramate, a glutamate-modulating agent, in patients with treatment-resistant obsessive-compulsive disorder (ocd) as an adjunct to serotonin reuptake inhibitors (sris). materials and methods: thirty-eight patients with refractory ocd, were randomly assigned to receive topiramate or placebo. this study was designed as a 12-week, double...

OBJECTIVE Comorbidity with personality disorders in obsessive-compulsive patients has been widely reported. About 40% of obsessive-compulsive patients do not respond to first line treatments. Nevertheless, there are no direct comparisons of personality traits between treatment-responsive and non-responsive patients. This study investigates differences in personality traits based on Cloninger's ...

One of the core behavioral features associated with obsessive compulsive symptomatology is the inability to inhibit thoughts and/or behaviors. Neuroimaging studies have indicated abnormalities in frontostriatal and dorsolateral prefrontal - anterior cingulate circuits during inhibitory control in patients with obsessive compulsive disorder compared with controls. In the present study, task perf...

The present study sought to replicate and extend a study by Abramowitz et al. (2009), who examined how well experiential avoidance (EA) and obsessive beliefs predicted obsessive-compulsive (OC) symptoms in a non-clinical sample. The current study utilized a severe, clinical, treatment-seeking sample (N=108), and examined how well EA and obsessive beliefs predicted changes in OC symptoms from pr...

Comorbidity is known to occur among various psychiatric disorders. About the third of the patients with Obsessive Compulsive Disorder have major depressive disorder and anxiety disorder but coexistence of Obsessive Compulsive Disorder with mania is rare to see. Here we report a case of Obsessive Compulsive Disorder where manic phase was accompanied by obsessions of contamination and pathologica...

background and aim: one of the common problems in people with obsessive-compulsive disorder and substance abuse is emotion regulation difficult. the aim of this study was to compare emotion regulation strategies in people with obsessive-compulsive disorder, substance abuse and normal people. materials and methods: this study was conducted with historical cohort method. 40 patients with ocd, 40 ...

a bstract  background: eating disorder symptoms are among the most common disorders in perinatal period and are influenced by various environmental and psychosocial factors such as anxiety disorders. so, the aim of this study was to determine the relationship between eating disorder symptoms and obsessive compulsive disorder in primigravida women.     materials and methods: this cross‑sectional...

objectives : since the symptoms of obsessive-compulsive disorder are basically culture-bound, identification and classification of the various kinds of symptoms prevalent among obsessive-compulsive patients have clinical significance. better identification of symptoms of obsession among iranian patients will result in quick and timely diagnosis of the disorder. further, it will be useful in dif...