PURPOSE Intracortical microinjection of fluorocitrate, a reversible inhibitor of glial tricarboxylic acid (TCA), results in impaired glial metabolism and epileptic seizures. To determine the potential contribution of epileptic activities to the metabolic properties of fluorocitrate, we investigated the seizure-inducing property of fluorocitrate at different doses. METHODS Twenty-seven male Sp...

Bye et al. in 1993 first described the pathological findings in a patient with celiac disease (CD), bilateral occipital calcifications, and drug-resistant epilepsy who became seizure-free after extensive occipital resection. We report a case with an identical anatomoclinical condition in which surgical removal of the circumscribed calcified lesion was ineffective and epilepsy worsened until a g...

occipital neuralgia is a condition manifested by chronic occipital headaches and is thought to be caused by irritation or trauma to the greater occipital nerve (gon). treatment for occipital neuralgia includes medications, nerve blocks, and pulsed radiofrequency ablation (prfa). landmark-guided gon blocks are the mainstay in both the diagnosis and treatment of occipital neuralgia. ultrasound is...

Posterior reversible encephalopathy syndrome (PRES) is a rare and severe neurotoxic encephalopathic state characterized by variable neurologic manifestations ranging from headache confusion to seizures, coma, subcortical vasogenic edema on imaging. PRES commonly induced chronic renal failure, hypertension, chemotherapeutic drugs, eclampsia. hypercalcemia uncommon not widely underlined in the li...

BACKGROUND Atypical clinical and imaging findings in Reversible Posterior Leukoencephalopathy Syndrome are recognized with increasing frequency. CASE REPORT We report a case of an adult in his 5(th )decade immunosupressed with methilprednisolone, tacrolimus and micophenolate who two months after renal transplantation, multiple infections and an episode of humoral rejection became hypertensive...

BACKGROUND The early visual areas have a clear topographic organization, such that adjacent parts of the cortical surface represent distinct yet adjacent parts of the contralateral visual field. We examined whether cortical regions outside occipital cortex show a similar organization. METHODOLOGY/PRINCIPAL FINDINGS The BOLD responses to discrete visual field locations that varied in both pola...

A 17-year-old boy developed increasing complex partial seizures, drowsiness, and a prolonged left hemiparesis. He had an extensive port wine nevus covering the left face, upper trunk, and limb (figure 1). Cranial CT and MRI confirmed the diagnosis of Sturge-Weber syndrome (figure 2, A–C). After receiving aspirin and anticonvulsant therapy,1 he recovered well and has been seizure-free over 2 yea...

The epileptic semiology of 19 patients (from 15 families) with mitochondrial disease due to mutations in the POLG1 gene is presented. The patients were either homozygous for the 1399G > A (p.A467T) or 2243G > C (p.W748S) mutations or compound heterozygotes for these two mutations. While the clinical features have been reviewed, detailed analysis of their epilepsy is presented for the first time...

A 4-year-old girl with Panayiotopoulos syndrome presented with a history of 4 prolonged autonomic seizures. The clinical features of her seizures included, in order of occurrence, blank staring, pallor, vomiting, hemi-clonic movement on the right side, and unresponsiveness. A brain magnetic resonance imaging (MRI) showed a slightly high T(2) signal in the left hippocampus. Interictal electoence...