Conjunctivochalasis (Cch) is a very common ocular disorder, which can cause an unstable tear film and ocular discomfort. The study of vision-related quality of life (VR-QoL) in a community population with Cch can provide a better understanding of the impact of Cch on common people than objective clinical examinations alone. This cross-sectional comparative study enrolled 360 participants ≥ 40 y...

Marija RADENKOVIĆ Clinic for Eye Diseases Clinical Center of Niš Bulevar dr Zorana Djindjića 48 18000 Niš Serbia [email protected] SUMMARY Introduction Ocular surface disease (OSD) is a multifactorial disease of the tears and ocular surface that results in symptoms of discomfort, visual disturbances, tear film instability with potential damage to the ocular surface, accompanied by increased tear ...

Ocular drug delivery in hydrogel forming film form has several benefits over conventional dosage forms. An ophthalmic anti-inflammation study was undertaken using topically applied aspirin a formulation. A hydroxypropyl methylcellulose (HPMC) matrix formulation prepared by the solvent casting and evaporation technique taking triethanolamine (TEA) as plasticizer. Ex vivo corneal permeation well ...

The concentration of ions, or osmolarity, in the tear film is a key variable in understanding dry eye symptoms and disease. In this manuscript, we derive a mathematical model that couples osmolarity (treated as a single solute) and fluid dynamics within the tear film on a 2D eye-shaped domain. The model includes the physical effects of evaporation, surface tension, viscosity, ocular surface wet...

PURPOSE To investigate the relationships between tear osmolarity and other ocular surface parameters and to determine the diagnostic value of tear osmolarity in primary Sjögren's syndrome (SS) using tear film break-up time, Schirmer I test, and cornea/conjunctiva staining. METHODS We included 310 eyes of 155 patients diagnosed with dry eye disease (39 primary SS and 116 non-Sjögren dry eye di...

Background: Tolmetin (Tol) is a pyrrole acetic acid derivative that acts as a highly effective topical anti-inflammatory agent. Topical administration of Tol is effective for the management of ocular inflammations.The aim of this study was to formulate and improve a topical ophthalmic delivery system of Tol. Materials and methods: In the present study, ocular inserts of Tol were prepared using ...

Dry eye is a multifactorial, progressive, and chronic disease of the tears and ocular surface. The disease is multi-factorial and has intermittent symptoms. Discomfort, visual disturbance, tear film instability with potential damage to the ocular surface, and increased tear film osmolarity are known associates. Dry eye is a common clinical problem for eye-care providers worldwide and there is a...

Polymers are tools used in novel drug delivery system to modify the drug release of pharmaceutical dosage form. Polyox is hydrophilic polymer made of non-ionic homopolymer of ethylene oxide. Polyox is popular for its film forming, binding, lubricating, mucoadhesive, viscosity imparting property in pharmaceuticals. Polyox are available in various grades based on its molecular weight. Lower molec...

PURPOSE To investigate use of an improved ocular tear film analysis protocol (OPI 2.0) in the Controlled Adverse Environment (CAE(SM)) model of dry eye disease, and to examine the utility of new metrics in the identification of subpopulations of dry eye patients. METHODS Thirty-three dry eye subjects completed a single-center, single-visit, pilot CAE study. The primary endpoint was mean break...

Diquafosol is a drug used for dry eye treatment with a novel mechanism of action. It stimulates the secretion of tear fluid and mucin on the ocular surface, thus enabling us to selectively treat the tear film layer, playing an important role in the establishment of the concept of "Tear Film Oriented Therapy (TFOT)", an effective therapeutic approach to dry eye in Japan. The 3% diquafosol ophtha...