purpose : to develop a guideline for the treatment of incompletely removed histopathologically documented ocular surface neoplasia (ossn) with mitomycin c (mmc). materials & methods : through an interventional case series, 17 eyes of 17 patients presented with incompletely removed ossn were treated according to a protocol using 2-3 alternate 7-day courses of mmc 0.04%. clinical recurrence was r...

ocular surface may be involved by different neoplastic lesions ranging from benign to highly malignant. recognition of risk factors, clinical presentations, pathology, and different therapeutic modalities is essential for selecting an appropriate approach. this article deals with the proper approach to ocular surface squamous neoplasia (ossn) including conjunctival/corneal intraepithelial neopl...

Current medical treatments of non infected resistant corneal ulcer include topical artificial tears, lubricants [1] and experimental trials of fibronectin [2], insulin-like growth factor type I [3] and substance P [3], autologous serum [4] or nerve growth factor [5]. When these medical therapies fail, one may consider patching, scleral contact lens, cyanoacrylate glue [6], conjunctival flap, ta...

Limbal epithelial stem cells (LESCs) are tissue-specific stem cells responsible for renewing the corneal epithelium. Acute trauma or chronic disease affecting LESCs may disrupt corneal epithelial renewal, causing vision threatening and painful ocular surface disorders, collectively referred to as LESC deficiency (LESCD). These disorders cannot be treated with traditional corneal transplantation...

AIMS To evaluate outcomes of deep anterior lamellar keratoplasty (DALK) in pediatric eyes with unilateral severe chemical injury which have undergone autologous simple limbal epithelial transplant (SLET). SETTINGS AND DESIGN The study design was a retrospective case series. MATERIALS AND METHODS This retrospective, case series of all children <16 years of age that have undergone DALK follow...

PURPOSE To culture and characterize oral mucosal epithelial cells (OMEC) grown on de-epithelialized human amniotic membrane (HAM) to explore their suitability as autografts in patients with bilateral ocular surface disease (OSD) and limbal stem cell deficiency. METHODS Oral biopsy samples were obtained from 20 patients undergoing oral reconstructive surgery, with informed consent and Institut...

PURPOSE OF REVIEW This article reviews the importance of ocular surface management in patients undergoing cataract surgery. The current strategies for the diagnosis and management of ocular surface disease in cataract surgery patients are discussed. RECENT FINDINGS The current trend is to diagnose and treat ocular surface disease before cataract surgery using a stepwise regimen tailored to th...