TRAIL is a recently described member of the TNF superfamily. The ability of TRAIL to induce apoptosis in a large number of tumors has stimulated interest in TRAIL as a tumor therapeutic agent. Although TRAIL mRNA is expressed in a number of tissues, its functional significance to various organs is unknown. Because tumors rarely develop in the eye, we have examined this organ for functional TRAI...

Role of the protein overexpression is very important in the pathogenesis, diagnosis and prognosis of neoplasia. Cases of overexpression of p53 and Ki67 proteins were investigated in 19 ocular squamous cell carcinomas (OSCC) in dairy cows. Microscopically, insix cases the tumors were carcinoma in situ (noninvasive carcinoma, G0), and in the remaining 13 cases the tumors were invasive carcinoma. ...

Immunohistochemical techniques were used to investigate the origin of a spindle cell tumor in the anterior uveal tract of dogs and the influence of ultraviolet radiation on the development of this tumor. Thirteen tumors were identified from the 4,007 canine ocular samples examined at the Comparative Ocular Pathology Laboratory of Wisconsin between 1978 and 2005. Siberian Husky and Siberian Husk...

The pivotal role of p53 in the regulation a vast array cellular functions has been subject extensive research. biological activity is not strictly limited to cell cycle arrest but also includes homeostasis, DNA repair, apoptosis, and senescence. Thus, mutations gene with loss function represent one major mechanisms for cancer development. As expected, due its key role, expressed throughout huma...

Impression cytology (IC) has been widely used as a method for evaluating the ocular surface and superficial cells layers in the diagnosis and follow-up after treatment of several ocular surface tumors of both epithelial and melanocytic origin. Information regarding this can be found in the English-language literature since 1992. Using either cellulose acetate or Biopore membranes for specimen c...

C ataracts normally occur in the later decades of life, which is also at a time when there is higher incidence of ocular tumors. Before a patient undergoes cataract surgery, it is important that surgeons perform a complete eye examination that includes careful funduscopy. The surgeon must be able to distinguish ocular tumors from other lesions and, should a lesion be identified, send patients f...

The 5th edition of the World Health Organization (WHO) Classification Tumours Eye and Orbit is latest step in standardizing diagnostic practice worldwide. Building upon 4th edition, published 2018, introduces new chapters on eyelid orbital tumors, consolidates sections hematolymphoid soft tissue bone metastases genetic tumor predisposition syndromes into dedicated chapters. Written format other...

Epiretinal Membrane (ERM) is characterized by wrinkling or distortion of macular surface caused by glial cell proliferation. It is a common disorder that affects visual acuity, especially in patients older than 50 years. Occasionally, ERM can develop in children and young adults. Epiretinal membranes are generally associated with ocular inflammatory or vascular diseases, tumors, trauma, and ocu...

RATIONALE Common ophthalmological problems are found in patients with eyelid tumors and include ocular surface diseases, such as dry eyes, eyelid disorders, excessive tearing and ocular inflammation. OBJECTIVE The potential correlation between the symptomatology, tear break-up time (TBUT) and lipocalin, lactoferrin and lysozyme concentrations in the tear film were investigated in a group of s...