BACKGROUND The progression from a benign pigmented lesion on the skin to cutaneous melanoma is better understood, and it could be presumed that a similar progression occurs with mucosal lesions. However, to our knowledge, there has never been documentation of melanosis transforming into melanoma over time. OBJECTIVE To describe a transformation of a mucosal melanosis into melanoma. METHODS ...

We present the case of a 12-year-old boy with Sturge-Weber syndrome and ocular melanocytosis who presented with bilateral naevus flammeus of the face and hyperpigmentation of the right iris associated with ipsilateral iris mammillations. The patient had glaucoma and a diffuse choroidal haemangioma of the right eye. Optical coherence tomography of the anterior segment confirmed iris hyper-pigmen...

Dermal melanocytosis refers to congenital or acquired lesions characterized by the presence of dendritic cells derived from melanocytes that migrate from the neural crest to the epidermis. The nevus of Ito develops in the territory supplied by the acromioclavicular nerve. Malignant transformation in dermal melanocytosis is extremely rare, with only isolated case reports; only 2 cases of maligna...

<p class="abstract">Phacomatosis pigmentovascularis is a rare group of syndromes characterized by the co-existence vascular nevus and pigmentary with or without extracutaneous systemic involvement. The existing classifications phacomatosis are based on phenotypic characteristics. We report case pigmentovascularis, flammeus, anaemicus dermal melanocytosis manifestations. molecular basis ye...

ABSTRACT First Person is a series of interviews with the first authors selection papers published in Disease Models & Mechanisms, helping researchers promote themselves alongside their papers. Weizhuo Wang author on ‘ Disrupting Hedgehog signaling melanocytes by SUFU knockout leads to ocular melanocytosis and anterior segment malformation', DMM. PhD student lab Ling Hou at Wenzhou Medical U...

Case presentation: A 2-year-old boy with Dandy-Walker syndrome diagnosed by obstetric ultrasound, presented diffuse and large nevi at birth. He was submitted to endoscopic third ventriculostomy 15 days old due obstructive hydrocephalus. Spinal fluid then sent for analysis but showed no melanocytes. MRI of the brain additional findings mutation could not be performed. After 1 month he needed a v...