Origin-Destination (OD) trip matrices, which describe the patterns of traffic behavior across the network, are the primary data input used in principal traffic models and therefore, a critical requirement in all advanced systems that are supported by Dynamic Traffic Assignment models. However, because OD matrices are not directly observable, the current practice consists of adjusting an initial...

The influence of the antibiotic linezolid on the secretion of exotoxins by Staphylococcus aureus was analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis combined with matrix-assisted laser desorption ionization-time of flight mass spectrometry and Western blot analysis. S. aureus suspensions were treated with grading subinhibitory concentrations of linezolid (12.5, 25, 50, and...

Oldenlandia diffusa (OD) is commonly used with various diseases such as cancer, arthritis, and autoimmune disease. Liver cirrhosis is a predominant risk factor for hepatocellular carcinoma (HCC). Here, we show that the therapeutic effect of OD, which was investigated both in vitro and chemically, induced HCC model. OD significantly enhanced apoptosis and antiproliferative activity and reduced m...

Adult offspring of severely diabetic pregnant rats are insulin resistant and display cardiovascular dysfunction. When pregnant they develop mild hyperglycaemia. Diets high in saturated fat have been implicated in the development of cardiovascular disease and vascular dysfunction. In the present study we have determined vascular function in small mesenteric arteries from offspring of normal (OC)...

Traffics of different regions in a city have different Origin-Destination (OD) patterns, which potentially reveal the surrounding traffic context and social functions. In this work, we present a visual analysis system to explore OD patterns of interested regions based on taxi trajectories. The system integrates interactive trajectory filtering with visual OD patterns exploration. Trajectories r...

Primary visual cortex (V1) is the site at which right and left eye pathways are first integrated, leading to a representation of the visual world in depth. The ocular dominance (OD) of individual cortical neurons varies and may be changed by altering visual experience during the developmental critical period. Estimates of OD, commonly used to quantify the right and left eye synaptic inputs, hav...

Urban road traac simulators sometimes require the turn probabilities at the intersections of the network they are simulating. This report describes a method for updating the given probabilities following the occurrence of a traac incident. Taking Dial's proportional assignment as the model of driver route choice behavior, we use a variant of Dial's algorithm to assign traac to the turns of the ...

BACKGROUND The complexity of fibre distributions in tissues is an important microstructural feature, now measurable in vivo by magnetic resonance imaging (MRI) through orientation dispersion (OD) indices. OD metrics have gained popularity for the characterisation of neurite morphology, but they still lack systematic validation. This paper demonstrates a framework for whole-sample histological q...

In oocyte donation (OD) pregnancies, there is a higher level of antigenic dissimilarity between mother and fetus compared with naturally conceived (NC) pregnancies. We hypothesize that a higher degree and/or a different type of immunoregulation is necessary to maintain an uncomplicated OD pregnancy. Different immunological aspects of successful OD pregnancies (n=28) were compared with those of ...

Background The oral selective phosphodiesterase-4 inhibitor roflumilast (ROF) reduces exacerbations in patients with severe COPD. Adverse events (AEs) can cause early ROF discontinuation. Alternative dosing strategies may help patients continue their therapy. Methods In this multicenter, double-blind trial, 1,321 patients with severe COPD were randomized 1:1:1 to 4 weeks' treatment with ROF 2...