T oday, 3D models of proteins are often constructed entirely by a computer. Building old-fashioned wire models may have been time-consuming, but it was not drudgery. To the contrary, it was a labor of love. One could not fail to marvel at the way in which the successive amino acids fitted together, with all the interactions making physical sense. However, the packing was not perfect. Here and t...

T oday, PLoS Biology publishes landmark metagenomics papers from the J. Craig Venter Institute's Global Ocean Sampling expedition [1–3]. These papers describe the initial analyses of several gigabasepairs' worth of sequence data from oceanic microbes collected during the Sorcerer II expedition, as the ship made her way down from Canada, through the Panama Canal, and fi nally out beyond the Gala...

T oday, Web search engines are the primary method for millions of users throughout the world to access information on a topic, navigate to Web sites, keep up with the news, and shop online. Most major search engines generate revenue via sponsored search, a process whereby content providers pay for traffic from specific links the search engine's display in response to user queries. Search engine...

1 Motivation Traditionally, the scale and scope of an experimental study was determined by the ability of the research team to generate data. Over the past few years, we h a ve been experiencing an unprecedented increase in the ability of small teams of experimental scientists to generate data. This has led to a shift in the balance between the diierent components of an experimental study. T od...

Please direct correspondence to Raymond Xu at [email protected] oday, due to its inherent specificity and sensitivity, the most prevalent bioanalytical technique in drug development is liquid chromatography tandem mass spectrometry (LC–MS-MS). This technique is regarded widely as the preferred tool for quantitative determination of drug and metabolites from biological matrices including pla...

1536-1268/02/$17.00 © 2002 IEEE T oday, mobile devices and gadgets come with more than just a cool and cutting-edge design; they come equipped with small brains and a common language, making them smarter and more powerful than ever before. Perhaps they’re a little too smart—after all, they can adapt and morph into each other and become many-in-one super devices. Mobile phones with PDA capabilit...

T oday, mobile devices and gadgets come with more than just a cool and cutting-edge design; they come equipped with small brains and a common language, making them smarter and more powerful than ever before. Perhaps they're a little too smart—after all, they can adapt and morph into each other and become many-in-one super devices. Mobile phones with PDA capabilities and PDAs packaged as mobile ...

Correspondence to: Dr M Stattin, Department of Sociology, Umeå University, Sweden; mikael.stattin@ soc.umu.se _________________________ T oday, most modern welfare states face the challenge of an aging population and decreasing rates of labour force participation among older people. Despite increased life expectancy, improved living conditions, and better health status, the average time people ...

oday, nearly half of humanity has no access to any type of sanitation (WHO and UNICEF 2000). The rest of humanity relies on conventional approaches to sanitation, which fall into one of two categories: water-borne systems and pit latrines. Both 'flush and discharge' and ' drop and store' technologies were built on the premise that the nutrients we excrete have little value, and that waste is su...

Open access, freely available online T oday the possibilities for a medical journal are almost limitless. The fi rst medical journals refl ected the needs of a closed group of doctors. But medicine, its place in the world, and the dissemination of information have changed utterly. So in starting afresh, what should a new medical journal retain, and what should it ditch? Most obviously, we shoul...