BACKGROUND AND AIMS C-myc over expression is implicated in malignancy although to date this has not been studied in Barrett's metaplasia. We sought to determine c-myc expression in the malignant progression of Barrett's metaplasia and whether it may be induced by bile acids seen in gastro-oesophageal refluxate. METHODS C-myc protein and mRNA levels were assessed in 20 Barrett's metaplasia and...

Metastasis to the odontoid peg is a rare condition. We report a case where such a metastasis from an oesophageal adenocarcinoma caused problems in both diagnosis and management. This is the first case to our knowledge to originate from a primary oesophageal adenocarcinoma. CASE REPORT. A 58 year old male was admitted with dysphagia and weight loss. Investigations revealed a lower oesophageal ad...

The oesophageal adenocarcinoma is an increasing pathology in the last decade, predominantly western population. A characteristic of esophageal cancer (EC) and esophageal-gastric junction (EGJC) high percent metastatic disease at time diagnosis one main causes death these patients. present case about a 78-year-old man, diagnosed with Barrett's esophagus high-grade dysplasia stenosis distal third...

The global obesity epidemic is contributing to increased prevalence of diseases fuelled by chronic inflammation, including cancer. Oesophageal adenocarcinoma (OAC) an obesity-associated malignancy with increasing prevalence, dismal prognosis, and severely dysregulated immune processes. We previously reported that αβ T cells migrate omentum liver in OAC contribute inflammation these tissues. Her...

Oesophageal cancer is divided into two main subtypes, squamous and adenocarcinoma. It is the eighth most common cancer in the world with squamous more common in the developing world and adenocarcinoma most prevalent in the developed world. Incidences of concomitant squamous carcinoma with adenocarcinoma are exceedingly rare with only a few documented occurrences in the form of case reports exis...

BACKGROUND A murine monoclonal antibody against the 17-1A epithelial antigen has been shown to be a useful adjuvant therapy in colorectal cancer. Its clinical use could be extended to patients with upper gastrointestinal adenocarcinoma. AIM To determine the distribution of the antigen in gastric and oesophageal adenocarcinoma. METHODS The activity of two monoclonal antibodies active against...

AIMS To investigate the pathological effects of preoperative chemotherapy on oesophageal carcinoma. METHODS Qualitative and quantitative changes in oesophageal carcinoma after preoperative chemotherapy were assessed by examination of biopsy specimens before treatment and resected specimens. RESULTS Of 13 patients with adenocarcinoma treated with 5-fluorouracil, adriamycin, and mitomycin (FA...