this paper is devoted to the study of determining optimal process mean in system production with the two markets for the sale of goods. in this paper, we developed an absorbing markov chain model in production systems where all items are inspected %100 for conformance with their specification limits. when the value of the quality characteristic of an item falls below a lower limit, the item is ...

temperature restrictions on aqueous effluents dictate that streams with a temperature higher than the permitted level needed to pass through cooling systems to reduce the effluent temperature before discharge. in this study, by considering the grouping design rules based on pinch technology, an optimum design for a distributed effluent cooling system, has been developed. a counter-flow wet cool...

avicenna (980 – 1037 ad) known as the prince of physicians in the west was one of the most prominent persian thinkers, philosophers, and physicians. owing to his interests in cardiology, he authored considerable works on different aspects of cardiology. “resaley-e-ragshenasi” (book on pulsology) and”kitab al-adviyt- ol-qalbiye” (the book on drugs for cardiovascular diseases) are avicenna’s grea...

background: prostate cancer after lung cancer is the second cause of cancer-associated death in men. in recent years, targeted therapy of cancer has attracted researchers attention. the targeted therapy lead to decrease in side effects of drugs. studies have indicated that targeting peptides for cancer cells represent valuable tools for diagnostic and therapeutic. recently, phage display peptid...

the purpose of this study, determining the optimal cultivation pattern by using interval mathematical programming approach among the farmers of esfarayen county before and after targeting the subsidies. for this purpose, farmers based on water resources classified in three group of using the river water, deep wells water and rainfed cultivation. the required data for this study has been obtaine...

Abstract Despite recent interests in developing lysine‐targeting covalent inhibitors, no general approach is available to create such compounds. We report herein a develop cell‐active inhibitors of protein kinases by targeting the conserved catalytic lysine residue using key SuFEx and salicylaldehyde‐based imine chemistries. validated strategy successfully (irreversible reversible) against BCR‐...

BACKGROUND In most African countries, indigents treated at public health centres are supposed to be exempted from user fees. In Africa, most of the available knowledge has to do with targeting processes in rural areas, and little is known about how to select the worst-off in an urban area. In rural communities of Burkina Faso, trials of participatory community-based selection of indigents have ...

MOTIVATION Off-target activity commonly exists in RNA interference (RNAi) screens and often generates false positives. Existing analytic methods for addressing the off-target effects are demonstrably inadequate in RNAi confirmatory screens. RESULTS Here, we present an analytic method assessing the collective activity of multiple short interfering RNAs (siRNAs) targeting a gene. Using this met...

In cropping systems, the precise application of herbicides is important for efficacious weed control. By using plant recognition and precision application technology targeting individual plants, off-target movement can be eliminated and herbicide rates significantly reduced without sacrificing yields. Highly targeted applications of nonselective herbicides into a growing sensitive crop are nove...

siVirus (http://siVirus.RNAi.jp/) is a web-based online software system that provides efficient short interfering RNA (siRNA) design for antiviral RNA interference (RNAi). siVirus searches for functional, off-target minimized siRNAs targeting highly conserved regions of divergent viral sequences. These siRNAs are expected to resist viral mutational escape, since their highly conserved targets l...