نتایج جستجو برای: oft

تعداد نتایج: 2797  

2010
Zhenhe Ma Aiping Liu Xin Yin Aaron Troyer Kent Thornburg Ruikang K. Wang Sandra Rugonyi

The measurement of blood-plasma absolute velocity distributions with high spatial and temporal resolution in vivo is important for the investigation of embryonic heart at its early stage of development. We introduce a novel method to measure absolute blood flow velocity based on high speed spectral domain optical coherence tomography (OCT) and apply it to measure velocities across the heart out...

Journal: :Development 2004
Huansheng Xu Masae Morishima John N Wylie Robert J Schwartz Benoit G Bruneau Elizabeth A Lindsay Antonio Baldini

Dysmorphogenesis of the cardiac outflow tract (OFT) causes many congenital heart defects, including those associated with DiGeorge syndrome. Genetic manipulation in the mouse and mutational analysis in patients have shown that Tbx1, a T-box transcription factor, has a key role in the pathogenesis of this syndrome. Here, we have dissected Tbx1 function during OFT development using genetically mo...

Journal: :Development 2012
Masahide Sakabe Hiroki Kokubo Yuji Nakajima Yumiko Saga

The progress of molecular genetics has enabled us to identify the genes responsible for congenital heart malformations. However, recent studies suggest that congenital heart diseases are induced not only by mutations in certain genes, but also by abnormal maternal factors. A high concentration of maternal retinoic acid (RA), the active derivative of vitamin A, is well known as a teratogenic age...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2014
Bruce D Smith

Even though the last 30 y has witnessed a remarkable increase in worldwide efforts to understand agricultural origins (OA), Gremillion et al. (1) find fault with the vast majority of this work, which they label as “particularism” and argue that it lacks sufficient inclusion of theory in the initial formulation of OA explanations. This label of particularism is applied to a remarkably broad spec...

Journal: :gynäkologie + geburtshilfe 2015

Journal: :pädiatrie: Kinder- und Jugendmedizin hautnah 2010

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