The effect of some amphipilic diblock-copolymers and comb-polymers on a balanced Winsor III microemulsion system is investigated with the quaternary system n-octyl-β-d-glucoside/1-octanol/n-octane/D2O as basis system. The diblock-copolymers are polyethyleneoxide-co-polydodecenoxide (PEO x PEDODO y ) and polyethyleneoxide-co-polybutyleneoxide (PEO x PEBU y ), constituted of a straight chain hydr...

The aim of the present study was to prepare, characterize and in-vitro evaluation of a Winsor-IV type microemulsion based drug delivery system incorporating celecoxib as BCS class–II model drug. Attempts were made to prepare cost effective O/W microemulsion using Tween 80, Glycerol, sunflower oil and water. The existence of microemulsion zone was investigated using phase diagrams. The systems w...

In this study, tretinoin microemulsion has been formulated based on phase diagram studies by changing the amounts and proportions of inactive ingredients, such as surfactants, co-surfactants and oils. The effects of these variables have been determined on microemulsion formation, particle size of the dispersed phase and release profile of tretinoin from microemulsion through dialysis membrane. ...

The use of an inorganic phase in water-in-oil (w/o) microemulsion has recently received considerable attention for preparing metal oxide nanoparticles. This is a technique, which allows preparation of ultrafine metal oxide nanoparticles within the size range 40 to 80 nm. Preparation of nano chromium (III) oxide studied investigated in the inverse microemulsion system. Therefore the nucleation o...

We examined the intradermal delivery of a hydrophilic polyphenol chlorogenic acid by in vitro study using excised guinea pig dorsal skin and Yucatan micropig skin. Skin accumulation as well as the solubility of chlorogenic acid in aqueous vehicles was much greater than for other polyphenols such as quercetin and genistein. However, since enhancement of skin delivery seemed to be necessary to ex...

We used microsecond time scale atomistic simulations to study the relaxation dynamics of the microemulsion water/octane/C(9)E(3) system. In order to determine what transport mechanism occurs under the conditions of surfactant excess, we studied the system under a wide range of temperatures (7-88 °C) and showed that the surfactant acts as an effective solvent for water and carries out passive wa...

BACKGROUND The increased incidence of inflammatory diseases has necessitated the need to search for new topical dosage form of dexamethasone. OBJECTIVES The purpose of the present study was the preparation and evaluation of novel microemulsion as a topical delivery system for dexamethasone by mixing appropriate amount of surfactant including Tween 80 and Labrasol, cosurfactant such as capryol...

In this study, tretinoin microemulsion has been formulated based on phase diagram studies by changing the amounts and proportions of inactive ingredients, such as surfactants, co-surfactants and oils. The effects of these variables have been determined on microemulsion formation, particle size of the dispersed phase and release profile of tretinoin from microemulsion through dialysis membrane. ...

In this study, tretinoin microemulsion has been formulated based on phase diagram studies by changing the amounts and proportions of inactive ingredients, such as surfactants, co-surfactants and oils. The effects of these variables have been determined on microemulsion formation, particle size of the dispersed phase and release profile of tretinoin from microemulsion through dialysis membrane. ...

The microstructure of the water rich microemulsion phase of the Cj~E~. water and decane system has been studied using surfactant ~H-NMR relaxation and 'H Fourier transform pulsed gradient spin-echo jFTPGSE) self-diffusion experiments. The surfactant-to-oil ratio is kept