This work establishes a new procedure for the extraction and analysis of pentacyclic triterpenes, with which fruits and leaves from three Spanish olive cultivars ("Picual", "Hojiblanca", and "Arbequina") has been studied. The leaf contains important amounts of oleanolic acid (3.0-3.5% DW), followed by significant concentrations of maslinic acid and minor levels of ursolic acid, erythrodiol, and...

Herein, we report the occurrence of four new compounds in ethanolic extract Albizia coriaria Welw ex. Oliver leaves along with other previously reported this species. The were isolated and characterized using column chromatography, Fourier Transform Infrared (FTIR) gas chromatography/mass spectrometry. FTIR spectrum showed phenolic OH stretching (3362.30 cm-1), C=O (1660.08 CO (1369.46 cm-1 131...

Tropical parasitic diseases such as Chagas disease and leishmaniasis are considered a major public health problem affecting hundreds of millions of people worldwide. As the drugs currently used to treat these diseases have several disadvantages and side effects, there is an urgent need for new drugs with better selectivity and less toxicity. Structural modifications of naturally occurring and s...

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus that caused global epidemic of COVID-19. 3C-like protease (3CLpro), called main (Mpro), cleaves 11 sites in long-stranded protein synthesized from viral genomic RNA. After cleavage protein, proteins such as RNA-dependent RNA polymerase are cut off and activated. Therefore, 3CLpro crucial for SARS-CoV-2 replication target ...

Triterpenoid saponins are bioactive metabolites that have evolved recurrently in plants, presumably for defense. Their biosynthesis is poorly understood, as is the relationship between bioactivity and structure. Barbarea vulgaris is the only crucifer known to produce saponins. Hederagenin and oleanolic acid cellobioside make some B. vulgaris plants resistant to important insect pests, while oth...

'Orujo' olive oil is obtained by chemical processes from the waste resulting from the mechanical extraction of virgin olive oil. The aim of the present study was to evaluate a new pharmacological property of two natural triterpenoids contained in olive oil, as vasodilatory agents, and to determine their mechanism of action. The two compounds studied were oleanolic acid and erythrodiol. The vaso...

Cancer Cell Pyroptosis In article number 2205531, Ke-Wu Zeng and co-workers describe the natural product oleanolic acid-based self-assembling nanostructures specially bind to proteasome subunit alpha 6 (PSMA6) activate for cancer cell pyroptosis. This study opens up a new direction development anti-cancer nanomedicine from resources.