The optic nerve often suffers regenerative failure after injury, leading to serious visual impairment such as glaucoma. The main inhibitory factors, including Nogo-A, oligodendrocyte myelin glycoprotein, and myelin-associated glycoprotein, exert their inhibitory effects on axonal growth through the same receptor, the Nogo-66 receptor (NgR). Oncomodulin (OM), a calcium-binding protein with a mol...

BACKGROUND BAP1 has been shown to be a target of both somatic alteration in high-risk ocular melanomas (OM) and germline inactivation in a few individuals from cancer-prone families. These findings suggest that constitutional BAP1 changes may predispose individuals to metastatic OM and that familial permeation of deleterious alleles could delineate a new cancer syndrome. DESIGN To characteriz...

BACKGROUND Omecamtiv mecarbil (OM) is a selective cardiac myosin activator that increases myocardial function in healthy volunteers and in patients with chronic heart failure. OBJECTIVES This study evaluated the pharmacokinetics, pharmacodynamics, tolerability, safety, and efficacy of OM in patients with acute heart failure (AHF). METHODS Patients admitted for AHF with left ventricular ejec...

BACKGROUND AND OBJECTIVES Family physicians deliver a significant proportion of occupational medicine (OM) services. In 1984, the American Academy of Family Physicians (AAFP) endorsed recommended curriculum guidelines in OM for family medicine residency programs. This study's purpose was to determine (1) whether family medicine residency programs have met the AAFP recommendations by providing r...

Optic morphology (Om) mutations in Drosophila ananassae are a group of retrotransposon (tom)-induced gain-of-function mutations that map to at least 22 independent loci and exclusively affect the compound eye morphology. In marked contrast to other Om mutations, which are characterized by fewer-than-normal and disorganized ommatidia, the Om(1E) mutation exhibits a peculiar phenotype as enlarged...

Currently, there is no commonly accepted methodology for developing organizational memory systems (OM) that is comprehensive in the sense that it guides the development process from beginning to end and is in sufficient detail to be implemented successfully. Using the ideas of memory metaphor and the user's perspective, we review recent work on OM through two dimensions: the stages of developin...

The autonomic and respiratory variables were studied in seven experienced meditators (with experience ranging from 5 to 20 years). Each subject was studied in two types of sessions--meditation (with a period of mental chanting of "OM") and control (with a period of non-targetted thinking). The meditators showed a statistically significant reduction in heart rate during meditation compared to th...

Previously (J. Liu, et al., Cell Growth Differ., 8: 667-676, 1997), we showed that oncostatin M (OM), a cytokine produced by activated T cells and macrophages, inhibited the proliferation of breast cancer cells derived from solid tumors and malignant effusions. OM-treated cells showed reduced growth rates and differentiated phenotypes. Because the p53 tumor suppressor protein plays an important...

OBJECTIVE To determine if cord blood anticapsular polysaccharide pneumococcal IgG antibody concentration was related to the number of otitis media (OM) and acute OM episodes during the first year of life. DESIGN Prospective study following infants from birth to 24 months. SETTING Health maintenance organization. PATIENTS The study population consisted of 415 infants whose mothers voluntee...