The proton pump inhibitor, omeprazole, surprisingly resulted in higher rates of proximal duodenal mucosal bicarbonate secretion than previously reported using an H2 receptor antagonist for gastric acid inhibition. Gastroduodenal perfusions were performed in healthy volunteers to evaluate whether this incidental finding is explained by more potent gastric acid inhibition by omeprazole or might b...

Preformulation is an important step in the rational formulation of an active pharmaceutical ingredient (API). Micromeritics properties: bulk density (BD) and tapped density (TD), compressibility index (Carr's index), Hauser's ratio (H), and sieve analysis were performed in order to determine the best excipients to be used in the formulation development of omeprazole magnesium enteric coated tab...

Giardiasis is highly prevalent in the developing world, and treatment failures with the standard drugs are common. This work deals with the proposal of omeprazole as a novel antigiardial drug, focusing on a giardial glycolytic enzyme used to follow the cytotoxic effect at the molecular level. We used recombinant technology and enzyme inactivation to demonstrate the capacity of omeprazole to ina...

Prof. Dr. C.B.H.W. Lamers, Department of Gastroenterology and Hepatology, University Hospital, Building 1, C4-P015, PO Box 9600, NL-2300 RC Leiden (The Netherlands) The manuscripts of the presentations given at the omeprazole introduction symposium, held in Maastricht on November 25, 1988, are published in this issue of Digestion. During this symposium entitled ‘Clinical Impact of H+-K+-ATPase ...

OBJECTIVE To evaluate the financial effects in a state employee health plan of a change in the drug coverage policy to include over-the-counter (OTC) omeprazole in a tier-copayment drug benefit design that favored the OTC drug. METHODS The policy change in the Arkansas State Employee Benefit Division (EBD) involved 2 principal parts: OTC omeprazole placed in a new OTC copayment tier (5 dollar...

Background: Heartburn occurs predominantly in the upper gastrointestinal tract and is associated with gastroesophageal reflux disease (GERD) gastritis. Omeprazole most prescribed proton pump inhibitor class of medication to treat heartburn related clinical conditions. To compare efficacy omeprazole 40 mg (as a total daily dose) 20 using patient-reported outcome measures (PROMs) patients due var...

lopidogrel is a prodrug activated in the liver to a metablite that is a specific and irreversible inhibitor of the platelet 2Y12 receptor. The P2Y12 receptor mediates the amplifiation of aggregation induced by adenosine diphosphate ADP) and also other agonists. In addition, P2Y12 inhibiion also affects coagulation and inflammation (1). These echanisms serve as the rationale for P2Y12 blockade i...

BACKGROUND Provocative tests for calcitonin (CT) are fundamental in the diagnosis and follow-up of C-cell disease and in the detection of hereditary medullary thyroid carcinoma (MTC) carriers with unknown RET mutations. A recent report has proposed omeprazole, which can increase endogenous gastrin (GT), as a new provocative test for MTC. METHODS We compared the omeprazole test (20 mg twice a ...

The effect of a proton pump inhibitor on gastrointestinal (GI) microbiota was evaluated. Eight healthy 9-month-old dogs (four males and four females) received omeprazole (1.1 mg kg(-1) ) orally twice a day for 15 days. Fecal samples and endoscopic biopsies from the stomach and duodenum were obtained on days 30 and 15 before omeprazole administration, on day 15 (last day of administration), and ...

A growing body of evidence has shown a broad variability in interindividual pharmacodynamic response profiles to the platelet inhibitor clopidogrel, and patients with reduced platelet inhibition have an increased risk of recurrent atherothrombotic events. Numerous factors may contribute to poor clopidogrel response. Among these, that secondary to a drug interaction with the proton pump inhibito...