Gram-negative bacteria maintain the barrier properties of the outer membrane (OM) in a wide array of physiological conditions despite their inability to degrade lipopolysaccharide (LPS) and protein material present in the outer leaflet of the OM. Through characterization of the native dynamics of outer membrane LPS change we recently described a mechanism in which these diderm organisms overcom...

Commensal bacteria impact host health and immunity through various mechanisms, including the production of immunomodulatory molecules. Bacteroides fragilis produces a capsular polysaccharide (PSA), which induces regulatory T cells and mucosal tolerance. However, unlike pathogens, which employ secretion systems, the mechanisms by which commensal bacteria deliver molecules to the host remain unkn...

Ontologies have seen quite an enormous development and application in many domains within the last years, especially in the context of the next web generation, the Semantic Web. Besides the work of countless researchers across the world, industry starts developing ontologies to support their daily operative business. Currently, most ontologies exist in pure form without any additional informati...

Current experimental vaccines against serogroup B Neisseria meningitidis are based on meningococcal outer membrane (OM) proteins present in outer membrane vesicles (OMV) in which toxic lipopolysaccharide is depleted by detergent extraction. Knowledge of the composition of OM and OMV is essential for developing new meningococcal vaccines based on defined antigens. In the current study, sodium do...

BACKGROUND Outer membrane vesicles (OMVs) released from Gram-negative bacteria can serve as vehicles for the translocation of virulence factors. Vibrio cholerae produce OMVs but their putative role in translocation of effectors involved in pathogenesis has not been well elucidated. The V. cholerae cytolysin (VCC), is a pore-forming toxin that lyses target eukaryotic cells by forming transmembra...

In this paper we aim at proposing metadata for expressing information about multilingual data in ontologies. Nowadays, and thanks to ontology metadata standards as the Ontology Metadata Vocabulary (OMV), ontology developers can have an effective access to all available ontological resources in the web. However, this metadata does not offer information about the linguistic properties of the reso...

This paper describes the application of OMV-R, an extension of the OMV metadata model for describing ontologies. The motivation is to help users searching for ontologies and ontology research related resources for reuse. In our extension we included information about ontology evaluation and evolution and we also propose more elaborated ways for describing ontology metrics. The extended model wa...

BACKGROUND Outer membrane vesicles (OMVs) are spheroid particles released by all Gram-negative bacteria as a result of the budding out of the outer membrane. Since they carry many of the bacterial surface-associated proteins and feature a potent built-in adjuvanticity, OMVs are being utilized as vaccines, some of which commercially available. Recently, methods for manipulating the protein conte...