REZUMAT University of Medicine and Pharmacy, Craiova, Romania The molecular pathogenesis of pituitary disorders is complex and has been explored in animal models and human subject studies. The endocrine (and pituitary) tumorigenesis process has particular aspects related to the dependency of the endocrine tissue on neurohormonal factors, that raise the probability of oncogene mechanisms activat...

Objective—The NF-êB/Rel family of transcription factors regulates the expression of many genes involved in the immune or inflammatory response at the transcriptional level. The aim of this study was to determine whether distinctive patterns of NF-kB activation are seen in diVerent forms of joint disease. Methods—The DNA binding activity of these nucleoproteins was examined in purified synovial ...

K N R K cells (a normal rat kidney [NRK] cell line transformed by Kirsten murine sarcoma vires) in sparse culture exhibit a highly ruffled morphology, but the cause of this ruffling is unknown. In this study, we have demonstrated that the continuous, excess ruffling on K N R K cells is caused by one or more soluble agents secreted by the K N R K cells themselves. To do this study, an assay for ...

K N R K cells (a normal rat kidney [NRK] cell line transformed by Kirsten murine sarcoma vires) in sparse culture exhibit a highly ruffled morphology, but the cause of this ruffling is unknown. In this study, we have demonstrated that the continuous, excess ruffling on K N R K cells is caused by one or more soluble agents secreted by the K N R K cells themselves. To do this study, an assay for ...