نتایج جستجو برای: oncogene
تعداد نتایج: 45009 فیلتر نتایج به سال:
Chronic myelogenous leukemia (CML) stem cells are the cellular source of vast majority mature CML and responsible for relapse disease post-tyrosine kinase inhibitor (TKI) therapy. Although cells, whose active division is driven by BCR-ABL1 oncogene-dependent signaling, reduced TKI therapy, resistant because they become quiescent via a heretofore elusive mechanism that independent oncogene signa...
with the present specifications for clasification, 95% of chronic myelogeneous leukaemia (cml) cases have the t(9;22), which brings the abl oncogene to the bcr region and results in a hybrid gene bcr/abl. there may be involvement of other chromosomes in 2-10%, and secondry or additional chromosome abberations may present in 60-80% during the progression of the disease. in the majority of the re...
The expression of c-sis proto-oncogene in bronchoalveolar mononuclear cells was studied in seven patients with pulmonary sarcoidosis. By means of nuclear run on transcription assay, the transcriptional level of c-sis proto-oncogene in bronchoalveolar mononuclear cells was investigated. Expression of c-sis proto-oncogene in bronchoalveolar mononuclear cells was enhanced. Enhancement of c-sis tra...
The smallest gene HBx of Hepatitis B virus (HBV) is recognized as an important viral oncogene (V-oncogene) in the hepatocarcinogenesis. Our previous work demonstrated that RMP is a cellular oncogene (C-oncogene) required for the proliferation of hepatocellular carcinoma (HCC) cells. Here we presented the collaboration between V-oncogene HBx and C-oncogene RMP in the development of HCC. The coex...
Downregulation of the ubiquitin-like containing PHD and ring finger 1 (UHRF1) oncogene in cancer cells response to natural anticancer drugs, including thymoquinone (TQ), is a key event that induces apoptosis. TQ can induce UHRF1 autoubiquitination via E3 ligase activity its RING domain, most likely through downregulation herpes virus-associated ubiquitin-specific protease (HAUSP). In this study...
The development of hematopoietic neoplasms is often associated with mutations, altered gene expression or chromosomal translocations. Recently, the t(5, 9)(q33;q22) translocation was found in a subset of peripheral T cell lymphomas and was shown to result in an IL-2-inducible kinase-spleen tyrosine kinase (ITK-Syk) fusion transcript. In this study, we show that T cell-specific expression of the...
Genetic damages are frequently found in both tumor and normal cells at carcinogen exposed areas in the patients with upper aerodigestive tract cancer. These phenomena are explained by the multistage process and/or field cancerization theories. The c-erbB-2 proto-oncogene has been amplified in many human tumors including breast, stomach, kidney and lung cancers. To study the possible evidence of...
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