Three-component reactions have emerged as useful methods because the combinationof three components to generate new products in a single step is extremely economical,among the multi-component reactions. A green, simple, efficient, and cost-effective procedure has been carried out by the synthesis of dihydropyrimidinonesin Biginelli’s condensation of ethyl cyanoacetate, aldehyde and urea or thio...

A convenient and efficient three-component reaction to a one-pot synthesis of thiophene derivatives from activated acetylenic compounds and ethyl 2chloroacetoacetate in the presence of tetramethyl thiourea in water lead to the formation of thiophenes in good yields.