Conservation of biological diversity is one the most important issues in conservation biology, so a wide range quantitative spatial methods have been used to determine biodiversity hotspots and priority areas. The main aims present study are determining areas endemism as well centers genus Onosma based on GIE, IPAs, species richness, AZE-like criteria approaches, assess status priorities mentio...

New treatment options are needed for medullary thyroid carcinoma (MTC), a highly metastasizing neuroendocrine tumor that is resistant to standard radiotherapy and chemotherapy. We show that the following shikonin derivatives inhibit cell proliferation and cell viability of the MTC cell line TT: acetylshikonin, β,β-dimethylacrylshikonin, shikonin and a petroleum ether extract of the roots of Ono...