Estrogen plus progestin hormone therapy (HT) is associated with an increased risk of postmenopausal breast cancer, but few studies have examined the impact of HT use on the risk of breast cancer in younger women. We assessed the association between estrogen plus progestin HT or unopposed estrogen HT and young-onset breast cancer using data from the Two Sister Study (2008–2010), a sister-matched...

PURPOSE PALB2 is a recently identified breast cancer susceptibility gene. We have previously identified in the Finnish population a PALB2 c.1592delT founder truncation mutation that is associated with an increased risk of breast cancer. In the present study, we wanted to assess in more detail the increased risk (hazard ratio, HR) and the age-specific cumulative risk (penetrance) of c.1592delT w...

Population-based breast and ovarian cancer family registries can facilitate studies to evaluate genetic and environmental factors in the etiology of these malignancies. The purpose of this study is to describe what is, as far as we know, the first population-based breast and ovarian cancer family registry and to estimate breast and ovarian cancer risk in relatives of breast and ovarian cancer p...

due to the high incidence of deaths from breast cancer, high cost of treatment and limited resources, the need to formulate and implement effective programs in reducing the burden of disease is obvious. care, control and creation of cancer information system having an infrastructure from collection of minimum data sets (mds) are the top priorities of research in iran's ministry of health.this i...

objectives: ziziphus jujube (jujube) plant has exhibited numerous medicinal and pharmacological properties including antioxidant and anti-inflammatory effects. this study was carried out to investigate its anti-cancer and pro-apoptotic abilities in human cervical and breast cancer cells in vitro. materials and methods: the cervical ov2008 and breast mcf-7 cancer cells were incubated with differ...

BACKGROUND BRCA1 and BRCA2 are the two major susceptibility genes involved in hereditary breast cancer. This study was undertaken to provide reliable population-based estimates of genetic influence and to characterize the nature and prevalence of BRCA1 and BRCA2 germline mutations in early-onset breast cancer. METHODS In a series comprising all women diagnosed with breast cancer under the age...

E pidemiological data suggest that 7% of breast cancer cases and 10% of ovarian cancer cases in the general population are attributable to one or more autosomal dominant susceptibility alleles. The breast and ovarian cancer susceptibility genes BRCA1 and BRCA2 were isolated in 1994 and 1995, 4 respectively, and since then, a large volume of literature attests to the involvement of these genes i...

E pidemiological data suggest that 7% of breast cancer cases and 10% of ovarian cancer cases in the general population are attributable to one or more autosomal dominant susceptibility alleles. The breast and ovarian cancer susceptibility genes BRCA1 and BRCA2 were isolated in 1994 and 1995, 4 respectively, and since then, a large volume of literature attests to the involvement of these genes i...

the evaluate the diagnostic value of image guided fine needle aspiration (fna) in breast lesions, the cytologic results of 401 patients were studied. all patients had either unpalpable masses or lesions who were hardly possible to localize by palpation and fna was performed by single radiologist under ultrasound guide in all cases. the cytologic results were divided into four categories (inconc...

background: in some verses in holy quran; 233 surat al-baghare , 15 al-ahghaf , 14 loghman and 6 al-talagh, breastfeeding, gravidity, and parity recommended to the parents and expected their children to be accountable to the parents; particularly to mothers due to tolerate of pregnancy and breastfeeding duration. methods: the case-control study included 376 patients diagnosed between      2001-...