Schizophrenia and bipolar disorders share not only clinical features but also some risk factors such as genetic markers and childhood adversity, while other risk factors such as urbanicity and obstetric complications seem to be specific to schizophrenia. An intriguing question is whether the well-established abnormal neurodevelopment present in many children and adolescents who eventually devel...

It has been reported that long-term memory function, including the semantic structure of category, is impaired in patients with schizophrenia. The present study was performed to determine: (1) whether the deficit in semantic structure in schizophrenia is independent of cultural backgrounds, and (2) the effect of age of onset and verbal intelligence on the degradation of semantic structure in th...

not perform the act. Another issue that needs discussion is the link between OCD and schizophrenia. Although OC symptoms are documented in association with schizophrenia (Rosen, 1957; Fenton and McGlashan,1986; Berman et al.,1995), phenomenological characteristics of OC phenomena that may predict the onset of schizophrenia is largely unknown. The onset of schizophrenic signs within two years of...

Background To describe the clinical, pathological, and molecular characteristics of late-onset (LO) dysferlinopathy patients. Methods Retrospective series patients with LO dysferlinopathy, defined by an age at onset symptoms ?30 years, from neuromuscular centers in France International Clinical Outcome Study for (COS). Patients early-onset (EO) (<30 years) were randomly selected COS study as a ...

The typical onset of schizophrenia during the transition from late adolescence to adulthood is one its central features. However, the neurodevelopmental hypothesis of schizophrenia has largely focused on the contribution of early development events. In this issue, we summarize data from a range of perspectives that emphasize the profound modifications occurring in anatomy, physiology, and funct...

BACKGROUND AND PURPOSE Mismatch in lesion visibility between diffusion-weighted image and fluid-attenuated inversion recovery image (DWI-FLAIR mismatch) has been proposed as a biomarker for the estimation of ischemic lesion age. The actual onset in some patients with unclear-onset stroke (UnCOS) may be close to the first-found abnormal time. We hypothesized that patients with UnCOS within a par...