نتایج جستجو برای: onset type load

تعداد نتایج: 1625129  

C. Nagarajan, M. Madheswaran,

This paper presents a Closed Loop CLL-T (capacitor inductor inductor) Series Parallel Resonant Converter (SPRC) has been simulated and the performance is analysised. A three element CLL-T SPRC working under load independent operation (voltage type and current type load) is presented in this paper. The Steady state Stability Analysis of CLL-T SPRC has been developed using State Space technique a...

Journal: :Human mutation 2005
Yonghong Li Paul Hollingworth Pamela Moore Catherine Foy Nicola Archer John Powell Petra Nowotny Peter Holmans Michael O'Donovan Kristina Tacey Lisa Doil Ryan van Luchene Veronica Garcia Charles Rowland Kit Lau Joseph Cantanese John Sninsky John Hardy Leon Thal John C Morris Alison Goate Simon Lovestone Michael Owen Julie Williams Andrew Grupe

Alzheimer disease (AD) is a complex neurodegenerative disorder predisposed by multiple genetic factors. Mutations in amyloid beta precursor protein (APP) are known to be associated with autosomal dominant, early onset familial AD and possibly also late onset AD (LOAD). A number of genes encoding proteins capable of binding to APP have been identified, but their contribution to AD pathobiology r...

Journal: :Alzheimers & Dementia 2021

Abstract Background The overarching goal of the Longitudinal Early‐onset Alzheimer Disease study (LEADS) is to optimally characterize early‐onset AD (EOAD) and establish an EOAD clinical trials network. Here we report baseline demographic imaging biomarker comparisons LEADS cohort late‐onset (LOAD) subjects from Alzheimer’s Neuroimaging Initiative (ADNI3). Method 123 amyloid‐positive EOAD, 47 a...

Journal: :Advances in Pediatrics 2016

Journal: :Journal of Alzheimer's disease : JAD 2012
Xiao-Ying Ma Jin-Tai Yu Zhong-Chen Wu Qun Zhang Qiu-Yan Liu Hui-Fu Wang Wei Wang Lan Tan

We conducted a replication study of the 2 genetic variants, rs11754661 and rs2073067, in MTHFD1L that have been recently reported to be associated with late-onset Alzheimer's disease (LOAD) in a genome-wide study in Caucasians. The associations were evaluated in a case-control sample comprising 1,189 Northern Han-Chinese individuals. The rs11754661 polymorphism is associated with LOAD (OR = 1.7...

2014
Ronnie Aronson Peter A. Gottlieb Jens S. Christiansen Thomas W. Donner Emanuele Bosi Bruce W. Bode Paolo Pozzilli

OBJECTIVE Previous studies demonstrated that the anti-CD3 monoclonal antibody otelixizumab, administered at a total dose of 48-64 mg, can slow the loss of C-peptide in recent-onset type 1 diabetes patients, with frequent reactivation of Epstein Barr virus (EBV). The DEFEND-1 (Durable Response Therapy Evaluation for Early or New-Onset Type 1 Diabetes) trial was designed to test whether a lower d...

Journal: :BMJ open diabetes research & care 2021

Introduction In type 1 diabetes, potential loss of life-years is greatest in those who are youngest at the time onset. Using data from a nationwide cohort patients with we aimed to study risk factor trajectories by age diagnosis. Research design and methods We stratified 30 005 diabetes aged 18–75 years into categories based on onset: 0–10, 11–15, 16–20, 21–25, 26–30 years. HbA1c, albuminuria, ...

Journal: :Scripta Scientifica Medica 2019

Journal: :Pediatric Neurology Briefs 2002

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