Onychomycosis is a common disease, accounting for up to 50% of all ungual pathologies. We have been developing a clinical trial (ClinicalTrials.gov: NCT01528813) using a 2940nm Er:YAG laser to fractionally ablate human nails in vivo, aiming to increase topical amorolfine lacquer delivery to the nail unit, increasing the efficacy of topical treatment of distal and lateral subungual onychomycosis...

Paecilomyces lilacinus, also known as Purpureocillium lilacinum, is a non-dermatophyte mold found in the soil and used as nematocide for crops. P. lilacinus can cause rare opportunistic infections in humans ranging from endocarditis, keratitis, to onychomycosis with significant resistance to conventional antifungals. There are only two cases of onychomycosis caused by P. lilacinus reported in t...

Onychomycosis is prevalent in the Canadian population, and risk factors, such as old age and diabetes, are increasing. This condition has traditionally been treated using oral antifungal agents with varying degrees of success. Recently, ciclopirox nail lacquer 8% solution became the first topical agent approved in Canada for onychomycosis. Ciclopirox nail lacquer may be safe and effective for t...

Onychomycosis is a fungal nail infection which is relatively common and difficult to treat. Treatment modalities include nail avulsion, surgical debridement and combination therapy with oral and topical antifungal drugs. In spite of a host of available drugs, clinical cure rates remain discouraging. Drug toxicities, prolonged regimens, lack of patient compliance, and high keratin affinity of dr...

4. Conant MA. The AIDS epidemic. J Am Acad Dermatol 1994; 9. Dompmartin D, Dompmartin A, Deluol AM, Grosshans E, Coulaud JP. Onychomycosis and AIDS. Clinical and laboratory 31: 47–50. findings in 62 patients. Int J Dermatol 1990; 29: 337–339. 5. Smith KJ, Skelton HG, Yeager J, Ledsky R, McCarthy W, 10. Weismann K, Knudsen EAK, Pedersen C. White nails in Baxter D, et al. Cutaneous findings in HI...

BACKGROUND Onychomycosis is a nail disorder associated with aesthetic problems, discomfort, physical injury and loss of dexterity. The purpose of the present study was to isolate and identify the causative fungi of onychomycosis in 2402 patients in Kermanshah Province, western Iran in 1994 to 2010. METHODS Mycologic assessment was carried out by standard methods including either microscopic o...

Onychomycosis is a fungal infection of nails seen frequently in immune competent and immune compromised patients due to dermatophytes, Candida spp., Fusarium spp., Scopulariopsis brevicaulis, Penicillium spp., and Aspergillus spp. We report a case of onychomycosis in a young immunocompetent male who presented onycholysis of a solitary nail without inflammation. The etiological agent was diagnos...

Clinicians must be aware of characteristics unique to certain populations when diagnosing and treating onychomycosis. For example, although onychomycosis is uncommon in children, it should be considered in the differential diagnosis when young patients have nail changes, particularly if a family history of onychomycosis is present. In elderly patients, comorbid medical conditions may complicate...

This study shows the effectiveness of photodynamic therapy based on methylene blue dye for the treatment of endonyx toenail onychomycosis. Four patients with endonyx onychomycosis caused by Trichophyton rubrum were treated with 2% methylene blue aqueous solution irradiated with light emission diode at 630 nm and an energy density of 36 J/cm2 for 6 months at 2-week intervals. The preliminary stu...