Discovered over a decade ago, white-opaque switching in the human fungal pathogen Candida albicans is an alternation between two quasistable, heritable transcriptional states. Here, we show that white-opaque switching and sexual mating are both controlled by mating type locus homeodomain proteins and that opaque cells mate approximately 10(6) times more efficiently than do white cells. These re...

Opaque colony variants of two strains of group A streptococci have been compared with blue colonies of the same strains by electron microscopy. In opaque colonies, the cocci are joined into elongated chains by exaggerated intercellular septa that often occupy the major portion of each cell's circumference. The thickness and lamination of cell walls in opaque colony variants are identical to tho...

3 results of this exercise tend to indicate that core mesh networks will remain opaque for some time. This column then explores the potential opportunity for cost reduction and scalability by introducing transparent switches in opaque networks. However, several challenges, both in technology and in network architecture, will have to be addressed before one can achieve the potential benefits of ...

Correspondence: CK Patel The Oxford Eye Hospital, West Wing, John Radcliffe Hospital, Headley Way, Headington, Oxford, OX3 9DU, United Kingdom Tel +44 18 6523 4736 Fax +44 18 6524 0097 Email [email protected] We read with great interest the recent article by Lee et al, who described their clinical experience with three patients who underwent primary implantation of Morcher (Stuttgart, Germ...

Companies in a variety of industries (e.g., airlines, hotels, theaters) often use last-minute sales to dispose of unsold capacity. Although this may generate incremental revenues in a short term, the long-term consequences of such a strategy are not immediately obvious: more discounted last-minute tickets may lead to more consumers anticipating the discount and delaying the purchase rather than...