Glaucoma and age-related macular degeneration (AMD) are the two leading causes of visual loss in the United States. We utilized a novel study design to perform a genome-wide association for both primary open angle glaucoma (POAG) and AMD. This study design utilized a two-stage process for hypothesis generation and validation, in which each disease cohort was utilized as a control for the other....

Purpose. To examine causes as well as extent of delay in diagnosis and treatment of primary open angle glaucoma patients in a sample of Egyptians. Patients and Methods. 440 patients with primary open angle glaucoma were interviewed to evaluate delay in their diagnosis and treatment. The extent and cause of delay were investigated. The total delay interval, if any, was correlated with socioecono...

OBJECTIVE To conduct a meta-analysis to estimate the relationship between primary open-angle glaucoma (POAG) and mortality. METHODS A systematic search of the PubMed, Embase, and Web of Science databases yielded 9 cohort studies with relative risk (RR) estimates for all-cause mortality. The studies were critically reviewed by an expert in the field. The data were extracted and analyzed in a p...

There has been an accumulation of evidence in recent years to demonstrate that surgical treatment is more effective than eyedrops at lowering intraocular pressure and preserving the visual field in primary open angle glaucoma.' 2 The argument against primary surgery for glaucoma has been the risk to the eye of performing an intraocular operation. The risks of topical medical therapy to general ...

Primary open-angle glaucoma (POAG) is one of the major causes of blindness worldwide and considered to be influenced by inherited and environmental factors. Recently, we demonstrated a genome-wide association study for the susceptibility to POAG by comparing patients and controls. In addition, the serum cytokine levels, which are affected by environmental and postnatal factors, could be also ob...

To assess the value of the provocative tests of glaucoma we investigated the water-drinking and jugular compression tests in about 140 eyes. Three groups of cases were investigated: (i) Normal eyes ... ... ... 50 (ii) Eyes with established glaucoma: (a) chronic simple glaucoma ... ... 33 (b) acute congestive glaucoma ... ... ... 13 57 (c) chronic congestive glaucoma ... ... 1 I J (iii) Pre-glau...

T he reduction of IOP remains the only course of action for primary openangle glaucoma (POAG), despite consistent observations of vascular risk factors such as low ocular perfusion pressure,1-4 vascular narrowing,5 and a higher incidence of risk factors associated with cardiovascular disease.6 As interest grows in a possible vascular role in the development of glaucoma, the number of articles o...

This study tests the hypothesis that abnormal motion displacement thresholds coexist with scotomas on a finer spatial scale than is measurable by conventional Humphrey perimetry. Eighteen patients with primary open angle glaucoma in one eye, and 18 age matched normal controls underwent motion displacement threshold testing and high spatial resolution perimetry. The motion displacement threshold...

We used background adaptation and silent substitution techniques to record full-field ON and OFF-visually evoked cortical potentials (VECPs) selectively from the S-cone and L- and M-cone pathways in 15 patients with primary open angle glaucoma (POAG), and 15 normal controls. The most statistically significant (P=0.01) VECP test for POAG was a voltage change in the S-cone pathway cortical OFF-re...