Aims of controlled oral food challenges are both to prove that a certain allergen plays a role for the individual clinical symptoms and to exclude food allergy in order to prevent the child from unnecessary or even harmful elimination diets. There are such types of challenges in the clinical practice: open, single-blind, or double-blind, placebo-controlled. Open OFC is an unmasked, unblinded fe...

at present the only available management for food allergy is avoidance; however, abstaining from allergic foods can affect the quality of life. oral immunotherapy (oit) is an efficient method for increasing tolerance towards food allergens. the aim of this study was desensitizing patients above five years of age with wheat allergy and evaluating the safety and efficacy of oit for children with ...

background: gestational diabetes mellitus (gdm) is the most common metabolic complications of pregnancy and causes fetal mortality and morbidity. therefore early diagnosis of gdm is necessary to reduce maternal and fetal morbidity and to help prevent or delay the onset of type 2 diabetes objective: this prospective study was carried out to determine the incidence of gdm in yazd and to assess th...

Cutaneous sensitization with a food antigen before its consumption elicits the development of food allergy. Here, we report the site- and stage-dependent roles of basophils and proallergic cytokines, thymic stromal lymphopoietin (TSLP) and IL-33, in a mouse model of food allergy initially sensitized cutaneously with the food antigen. Mice were epicutaneously sensitized with the food antigen ova...

BACKGROUND The diagnostic accuracy of the skin prick test (SPT) for food allergies remains to be fully accepted and substantial individual differences in the prevalence of skin test reactivity have been reported. OBJECTIVE The aim of this study was to assess the diagnostic value of absolute wheal size and skin index (SI; ratio of food allergen-induced wheal to histamine-induced wheal) accordi...

BACKGROUND Positive skin prick test reactions to carmine red (E120) occur in approximately 3% of the patients studied for food allergy. Carmine ingestion associated systemic symptoms are occasionally suspected, but sufficient information of proven carmine allergy is not available. PATIENTS AND METHODS To analyse carmine related symptoms in skin prick test positive patients a cohort of 23 pati...

BACKGROUND Since the first suggestion of threshold values for food specific IgE antibody levels in relation to clinical reactivity, several authors have proposed different threshold values for different allergens. We investigated the relationship between wheat/soybean specific IgE antibody levels and the outcome of wheat/soybean allergy diagnosis in children of different ages. METHODS A retro...

BACKGROUND Oral food challenges (OFCs) are performed for diagnosis of a food allergy in cases where the allergy is not supported by patient history, or when a newly developed tolerance level needs to be established. OBJECTIVE We aimed to investigate the prevalence and severity of reactions during OFCs in preschool children. METHODS A retrospective study was conducted on children younger tha...