Silybin or silibinin, a flavonolignan isolated from Milk thistle seeds, is one of the popular dietary supplements and has been extensively studied for its antioxidant, hepatoprotective and anti-cancer properties. We have envisioned that potency of silybin could be further enhanced through suitable modification/s in its chemical structure. Accordingly, here, we synthesized and characterized a se...

alpha-Ethyltryptamine (alpha-ET) possesses central stimulant and hallucinogenic activity. Also, in tests of stimulus generalization using rats trained to discriminate the controlled substance analog (i.e., designer drug) N-methyl-1-(3,4-methylenedioxyphenyl)-2-aminopropane (MDMA) from vehicle, alpha-ET substituted for MDMA. These previous studies employed racemic alpha-ET. Because psychoactive ...

The metalloligand [Ni(pedt)2](-) (pedt = 1-(pyridine-4-yl)ethylene-1,2-dithiolate) has been incorporated into two multi-dimensional structures for the first time. These coordination frameworks represent highly unusual interpenetration isomers and exhibit solid state redox and optical properties that reflect the electronically delocalised nature of the metalloligand.

This study demonstrates the stereoselective metabolism of the optical isomers of omeprazole in human liver microsomes. The intrinsic clearance (CL(int)) of the formation of the hydroxy metabolite from S-omeprazole was 10-fold lower than that from R-omeprazole. However, the CL(int) value for the sulfone and 5-O-desmethyl metabolites from S-omeprazole was higher than that from R-omeprazole. The s...

Several years ago experiments were undertaken in this laboratory for the purpose of determining the minimum amount, of each indispensable amino acid which must be included in the food in order to induce maximum growth in the rat. This was accomplished by varying the proportion of one amino acid while maintaining the concentrations of all others at constant levels. Throughout the tests, liberal ...

The optical isomers of tryptophan have generally been regarded as equally effective in promoting the growth of rats. This opinion is based upon the results of early investigations (l-3) in which the dietary conditions then necessarily employed were hardly comparable to those used in present day studies. Experimental diets are now more adequately supplemented with vitamins, and possess other qua...

The ways of binding optically active ligands, mainly of the amino acid type, to cross—linked polymers of styrene, acrylamide or glycidylmethacrylate are reviewed. When coordina— ted to transition metal ions, these polymers display a high discriminating ability in sorption of optical isomers of corn— pounds capable of forming mixed—ligand complexes. The kinetic performance of the ligand—exchangi...