AIM Many studies have suggested that a lesion originally diagnosed as oral lichen planus (OLP) has different possibilities of undergoing malignant transformation in time, although these findings remain a controversial issue; for example, some studies reported different values of potential malignancy of OLP. INTRODUCTION World Health Organization (WHO) classifies OLP as a "potentially malignan...

STATEMENT OF THE PROBLEM Lichen planus is a mucocutaneous disease that is relatively common in middle aged individuals. Some studies have shown that oral lichen planus has a potential to progress to squamous cell carcinoma.p21 is a cyclin-dependent kinase inhibitor that regulates the cell cycle, thus it acts as an inhibitor in cell proliferation. PURPOSE This study was aimed to evaluate and c...

Oral lichen planus is a chronic inflammatory disease that affects the mucous membrane of the oral cavity and can contribute to the development of other diseases. Inflammation in oral lichen planus is a T-cell-mediated autoimmune disease that acts through cytotoxic CD8(+) T cells to trigger apoptosis of keratinocytes. However, the specific cause of oral lichen planus remains unknown and no effec...

BACKGROUND AND AIMS The clinical management of oral lichen planus poses considerable difficulties to the clinician. In recent years, researchers have focused on the presence of pathogenic microorganisms such as Candida albicans in the patients with refractory lichen planus. The aim of the present study was to investigate the prevalence of candida species in the erosive oral lichen planus lesion...

introduction: oral lichen planus (olp) is a common mucocutanous disorder with unknown etiology. while current data suggest that oral lichen planus is a cell-mediated autoimmune disease, it might be associated to s+100, cd+4 and cd+8 cells. because of differential diagnosis of olp and oral lichenoid lesion (oll) is usually difficult this study was designed to compare any probable immunohistochem...

BACKGROUND Topical tacrolimus has been reported to be effective for the treatment of oral lichen planus. This article describes our experience with topical tacrolimus in patients treated for symptomatic oral lichen planus. OBSERVATIONS A survey was mailed to 40 patients with symptomatic oral lichen planus treated with topical tacrolimus. Surveys were completed by 37 patients (93%) a mean of 1...

BACKGROUND Oral lichen planus and mouth dryness are common pathoses, yet not entirely understood. These two conditions may be associated, with a few studies investigating the relationship between mouth dryness and oral lichen planus providing conflicting results. None of the studies have explored the specific impact of disease treatment on mouth dryness. OBJECTIVE The purpose of this observat...

Dysphagia is not uncommon in gastroenterology practice. The differential diagnosis is wide and includes both mechanical and motility causes. Esophageal lichen planus is uncommon but now increasingly recognized. It occurs in more than half of cases of lichen planus with muco-cutaneous involvement. Often there is a delay in diagnosis and subsequent treatment. The endoscopic picture of esophageal ...

INTRODUCTION Lichen planus is an immune mediated inflammatory lesion involving skin and mucosal sites including oral mucosa, vulva and rarely vagina. Lichen planus occurring at mucosal sites has been shown to be associated with squamous cell carcinoma in a proportion of cases. To the best of our knowledge, no case of lichen planus of uterine cervix has been reported in the available literature....