BACKGROUND The relationship between oral lesions arising from HIV infection and CD4/CD8 cell ratios is of relevance in clinical assessment of immune suppression. OBJECTIVE To correlate the prevalence of oral manifestations arising from HIV infection and the levels of CD4/CD8 cell ratios. DESIGN A cross-sectional study. SETTING Kenyatta National Hospital, Nairobi, Kenya. SUBJECTS Two hun...

A phase I trial of PF-03084014, an oral reversible γ-secretase inhibitor, in solid tumor malignancies shows drug tolerability in patients. Evidence of Notch pathway inhibition was demonstrated in peripheral blood. A surprisingly high rate of response was seen in desmoid tumors, a rare but sometimes locally aggressive sarcoma.

background: bone sarcomas are the most common malignancies of bone tissues in children, and are classified intotwo groups as osteosarcoma and ewing’s sarcoma. treatment and prognosis depend on the subtype and grade ofthe tumor. the goal of this study was to evaluate the features bone sarcoma in patients referred to mahak childrenhospital since 2007 to 2009.materials and methods: this was a retr...

although rare, synovial sarcoma is the most common malignant non-rhabdomyosarcomatous soft tissue sarcoma in children and adolescents. synovial sarcoma typically involves the soft tissues of the extremities, especially near large joints, but it can occur anywhere in the body in locations far from joint spaces. although this tumor typically affects adults in their fourth decade of life, nearly h...

we report a 75 year - old man who presented with a cervical mass, dysphagia anil hoarseness, ct - xcan of neck showed a large cold nodule in the right lobe of thyroid gland, which was followed by surgical excision and its histopathologic exam revealed well-differentiated chondrosarcoma.

INTRODUCTION Myeloid sarcoma is a rare extramedullary malignant tumor composed of immature myeloid cells. The tumor can affect any part of the body. Involvement of the oral cavity and nasopharynx has been reported in 50 cases. We report a case describing myeloid sarcoma affecting the lateral pharyngeal wall. CASE PRESENTATION A 31-year-old Arabian man who had acute biphenotypic leukemia treat...

OBJECTIVES/HYPOTHESIS The aim of this study was to evaluate the efficacy and safety of intralesional bevacizumab, a monoclonal antibody against vascular endothelial growth factor, in patients with human immunodeficiency virus (HIV)-associated Kaposi's sarcoma of the upper airway receiving antiretroviral therapy. STUDY DESIGN A pilot randomized, open, phase II study. METHODS HIV-infected pat...

Dr Lawson is professor of otolaryngology at the Mount Sinai School of Medicine in New York City. WILLIAM LAWSON, MD, DDS Mount Sinai School of Medicine I f you know what to look for, the appearance of a puzzling oral lesion can help you narrow the possible causes. In previous issues of CONSULTANT (April 2012, page 301, and May 2012, page 347), I provided tips for identifying and managing white ...

BACKGROUND Ewing's sarcoma cells express c-kit, a receptor tyrosine kinase, and its ligand, stem cell factor (SCF), creating a potential autocrine loop that may promote tumor survival. We thus examined whether the specific tyrosine kinase inhibitor imatinib mesylate (hereafter imatinib; formerly STI571) could inhibit the proliferation of Ewing's sarcoma cells in vitro and in vivo. METHODS The...