BACKGROUND There is still significant risk of patients developing surgical site infection (SSI) following orthopaedic surgery due to growing demand for joint surgery in high-risk patients and increasing complexity of procedures. The higher rate of SSI seen in high-risk procedures and also in high-risk patients is of concern as the development of infection can be a very serious complication of o...

Introduction: Reconstruction of the hip after the resection of a pelvic tumor is a challenging procedure in orthopaedic oncology. The use of massive allograft reconstruction may restore the pelvic architecture and provide a suitable bone stock for acetabular prosthetic implant. The major complication is deep infection whatever the method of reconstruction applied; however, high mechanical compl...

Biomaterial integration in bone depends on bone remodelling at the bone-implant interface. Optimal balance of bone resorption by osteoclasts and bone deposition by osteoblasts is crucial for successful implantation, especially in orthopaedic surgery. Most studies examined osteoblast differentiation on biomaterials, yet few research has been conducted to explore the effect of different orthopaed...

The introduction of finite element analysis (FEA) into orthopaedic biomechanics allowed continuum structural analysis of bone and bone-implant composites of complicated shapes (Huiskes and Chao, J. Biomechanics, Vol. 16, 1983, pp. 385-409). However, besides having complicated shapes, musculoskeletal tissues are hierarchical composites with multiple structural levels that adapt to their mechanic...

Implant-associated infection is becoming more and more challenging to the healthcare industry worldwide due to increasing antibiotic resistance, transmission of antibiotic resistant bacteria between animals and humans, and the high cost of treating infections. In this study, we disclose a new strategy that may be effective in preventing implant-associated infection based on the potential antimi...

Removal of hardware in orthopaedic surgery is usually encountered in revision fracture surgery for non union, mal union, infection and peri-implant failure. If the hardware has broken this can make revision surgery even more demanding. Numerous techniques have been described to facilitate implant removal. A broken femoral nail is not an uncommon presentation of a delayed union or a non union. W...