OBJECTIVE This is the first report of successful allograft mosaicplasty treatment of a large osteochondral lesion of the knee caused by a blast fragment sustained during combat operations. The patient was able to return to active duty following rehabilitation. METHODS An active-duty infantryman sustained an osteochondral lesion of the medial femoral condyle caused by a metallic fragment of an...

Given articular cartilage has a limited repair potential, untreated osteochondral lesions of the ankle can lead to debilitating symptoms and joint deterioration necessitating joint replacement. While a wide range of reparative and restorative surgical techniques have been developed to treat osteochondral lesions of the ankle, there is no consensus in the literature regarding which is the ideal ...

Symptomatic osteochondral lesions of the knee pose a considerable treatment challenge to orthopaedic surgeons, particularly when they occur in young active patients. The prognosis of osteochondral defects is worse when the defect is sizable, when it is located in a weight-bearing portion of the knee, and when there is considerable bone loss. Hyaline cartilage is unable to heal spontaneously bec...

BACKGROUND AND PURPOSE Osteochondral defects have a limited capacity for repair. We therefore investigated the effects of tumor necrosis factor (TNF) signal blockade by etanercept (human recombinant soluble TNF receptor) on the repair of osteochondral defects in rabbit knees. MATERIAL AND METHODS Osteochondral defects (5 mm in diameter) were created in the femoral patellar groove in rabbits. ...

We performed eight osteochondral autologous transplantations from the knee joint to the shoulder. All patients (six men, two women; mean age 43.1 years) were documented prospectively. In each patient the stage of the osteochondral lesion was Outerbridge grade IV with a mean size of the affected area of 150 mm2. All patients were assessed by using the Constant score for the shoulder and the Lysh...

Our aim in this prospective study was to determine the best diagnostic method for discriminating between patients with and without osteochondral lesions of the talus, with special relevance to the value of MRI compared with the new technique of multidetector helical CT. We compared the diagnostic value of history, physical examination and standard radiography, a 4 cm heel-rise view, helical CT,...

Knee osteochondral lesions can be debilitating. Multiple procedures have been used to manage these defects. Osteochondral autograft transplantation is one such option. Reported complications include donor-site morbidity, failed osteointegration, size mismatch, and incongruency. In this article, we report a case of graft incongruency of the medial femoral condyle that resulted in a full-thicknes...

background and objectives : examination of cartilage repair in animal work is dependent upon the thickness and radius of the induced impalement.  full-thickness defects with a radius of 3 mm have been commonly used in animal studies to evaluate new procedures designed to improve the quality of articular cartilage repair. the aim of the present study was to define the biomechanical characteristi...

Osteochondral lesions of the ankle are a more common source of ankle pain than previously recognized. Although the exact pathophysiology of the condition has not been clearly established, it is likely that a variety of etiological factors play a role, with trauma, typically from ankle sprains, being the most common. Technological advancements in ankle arthroscopy and radiologic imaging, most im...

BACKGROUND Replacement of diseased areas of the joint with tissue-engineered osteochondral grafts has shown potential in the treatment of osteoarthritis. Bioactive glasses are candidates for the osseous analog of these grafts. QUESTIONS/PURPOSES (1) Does Bioactive Glass 13-93 (BG 13-93) as a subchondral substrate improve collagen and glycosaminoglycan production in a tissue-engineered cartila...