This work focuses on designing bilayered constructs by combining electrospun poly-DL-Lactide (PDLLA) fibers and Bioglass®-derived scaffolds for development of osteochondral tissue replacement materials. Electrospinning was carried out using a solution of 5 wt/v% PDLLA in dimethyl carbonate. The PDLLA layer thickness increased from 2 to 150 µm with varying electrospinning time. Bioactivity studi...

Symptomatic osteochondral lesions of the knee pose a considerable treatment challenge to orthopaedic surgeons, particularly when they occur in young active patients. The prognosis of osteochondral defects is worse when the defect is sizable, when it is located in a weight-bearing portion of the knee, and when there is considerable bone loss. Hyaline cartilage is unable to heal spontaneously bec...

PURPOSE To determine clinical results after combined femoral osteochondral allograft and meniscus transplantation. METHODS Thirty-two patients with a minimum 2-year follow-up were identified who had previously undergone combined meniscus allograft transplantation and fresh osteochondral allograft transplantation. Demographic and intraoperative data, including condylar defect size, as well as ...

 Background: To determine the efficacy of different antiseptic solutions (Control group (I), Antibiotic solution (II), Chlorhexidine 0.4% (III), and povidone – iodine 10% (IV)) in sterilizing contaminated osteochondral plugs. Methods: Under sterile conditions, the femoral head and condyles of 20 rabbits were removed and cut into equal osteochondral pieces. A total of 200 osteochondral specimens...

Mesenchymal stem cells (MSCs) from bone marrow play a critical role in osteochondral repair. A bone marrow clot forms within the cartilage defect either as a result of marrow stimulation or during the course of the spontaneous repair of osteochondral defects. Mobilized pluripotent MSCs from the subchondral bone migrate into the defect filled with the clot, differentiate into chondrocytes and os...

The purpose of this study was to examine the effect of tenascin-C (TNC) on the repair of full-thickness osteochondral defects of articular cartilage in vivo. We used a gellan-gellan-sulfate sponge (Gellan-GS) to maintain a TNC-rich environment in the cartilage defects. We implanted Gellan-GS soaked in PBS only (Group 1), Gellan-GS soaked in 10 µg/ml of TNC (Group 2), and Gellan-GS soaked in 100...

BACKGROUND The treatment of articular cartilage defects is a therapeutic challenge for orthopaedic surgeons. Furthermore, large osteochondral defects needs restoration of the underlying bone for sufficient biomechanical characteristics as well as the overlying cartilage. CASE PRESENTATION A symptomatic large osteochondral defect in the knee joint was restored using a composite of umbilical co...

Magnetic resonance imaging (MRI) and arthroscopy have frequently been used to evaluate articular cartilage. Many studies have compared the accuracy of MRI to that of arthroscopy. However, there have been no previous comparison studies between MRI and arthroscopy in the evaluation of repaired cartilage after autologous chondrocyte implantation using the Magnetic Resonance Observation of Cartilag...

INTRODUCTION MRI is commonly used to evaluate athletes with elbow pain. MRI can acquire high resolution images with excellent tissue contrast in multiple planes. It is therefore well-suited for assessing the bones, ligaments, tendons and nerves of the elbow which may all be sources of pain in athletes. MRI is particularly helpful for evaluating athletes with non-localisable elbow pain and athle...

BACKGROUND We have recently found a phenomenon that spontaneous regeneration of a hyaline cartilage-like tissue can be induced in a large osteochondral defect by implanting a double-network (DN) hydrogel plug, which was composed of poly-(2-Acrylamido-2-methylpropanesulfonic acid) and poly-(N, N'-Dimetyl acrylamide), at the bottom of the defect. The purpose of this study was to clarify gene expr...