A structure–activity relationship (SAR) study in terms of G-quadruplex binding ability and antiproliferative activity six fluorescent perylenemonoimide (PMIs) derivatives is reported. positive charge seems to be the key target G4. This also reveals importance element substitution potential biological PMIs, being polyethylene glycol (PEG) chains peri position responsible for their activity. Amon...

The patient is a 71-year-old woman with serous ovarian cancer hospitalized for asthenia digestive hemorrhage. At esophagogastroduodenoscopy, protruding mass was noted at the level of gastric antrum. She underwent hemostasis an endoscopic by argon plasma; effective hemostasis. final pathology revealed metastases adenocarcinoma. Weekly gemcitabine chemotherapy adopted, but disease progressed rapi...

Background: The ovarian tumors with functioning stroma are defined by the morphological presence of endocrine active cells in stroma, and the clinical, biochemical or pathological evidence of endocrine function. Case Report: The ovarian endometrioid adenocarcinoma with functioning stroma accompanied with endometrial endometrioid adenocarcinoma was found in 64-year-old post-menopausal woman comp...

Fallopian adenocarcinoma is a rare malignancy arising in the epithelium of the fallopian tube. Fallopian tube epithelium has been proposed as a tissue origin for high-grade serous ovarian carcinoma, the deadliest gynecologic malignancy. Given the commonalities in dissemination and treatment of these malignancies, we contemplated the possibility of similar patterns of gene expression underlying ...

BACKGROUND Malignant transformation in endometriosis is a rare but well known complication. However, detailed mechanisms of malignant transition and tumourigenesis in endometriosis remain unknown. We here describe the case of an endometrioid carcinoma arisen in endometriotic ovarian cyst fulfilling Sampson's criteria for malignant transformation of endometriosis. We compared genetic alterations...

BACKGROUND: Germline mutations in BRCA1/2 greatly elevate risks of breast and ovarian cancers, but the role of these genes in tumourigenesis of other cancer types is still being investigated. OBJECTIVE: We report on an investigation of BRCA1/2 mutations and their loss of heterozygosity (LOH) in a patient with a strong family history of breast cancer who was diagnosed with consecutive primary ce...

We report 2 cases of synchronous ovarian and endometrial tumour presented to us with irregular bleeding per vagina. Case 1: 51 year old, nulliparous lady came with irregular vaginal bleeding with mass per abdomen. Ultrasonogram of pelvis showed bulky heterogeneous uterus with solid and cystic lesions in both adnexa.CA125 was 293 IU/ml. Patient underwent staging laparotomy with radical hysterect...

This leader reviews recent advances in immunohistochemistry that are useful in the diagnosis of ovarian neoplasms. These include the value of different anticytokeratin antibodies in the distinction between a primary ovarian adenocarcinoma and a metastatic adenocarcinoma, especially of colorectal origin. These antibodies have also helped to clarify the origin of the peritoneal disease in most ca...

This leader reviews recent advances in immunohistochemistry that are useful in the diagnosis of ovarian neoplasms. These include the value of diVerent anticytokeratin antibodies in the distinction between a primary ovarian adenocarcinoma and a metastatic adenocarcinoma, especially of colorectal origin. These antibodies have also helped to clarify the origin of the peritoneal disease in most cas...