Granulosa cell tumors of the ovary are malignancies that originate from the sex-cord stromal cells of the ovary and represent 2% to 5% of all ovarian cancers. Slow growth with a tendency for late recurrence characterizes a natural history of this tumor. So this tumor needs a prolonged follow-up. As a result of recent literature in Korea, the findings are 3 cases of juvenile granulosa cell tumor...

It would be desirable to expand the existing general knowledge concerning direct action of metals on the ovary. Nevertheless, the results of testing of iron compound on porcine ovarian cells should be interpreted carefully because iron is an essential element which could also induce changes in cellular processes. The aim of this in vitro study was 1) to examine dose-dependent effects of iron on...

Granulosa cells play an important part in the nutrition of the oocyte during oogenesis (Raven, 1961). Anderson & Beams (1960) suggested that, in the primary follicle, nutritive material synthesized by the granulosa cells reaches the oocyte by diffusion across the zona pellucida. In the rabbit, follicle formation and elaboration of the zona pellucida begin at the end of the second week after bir...

SUMMARY 14 15 The obtained data could expand the existing general knowledge concerning direct action of 16 metals on the ovary. Nevertheless, the results of testing of iron compound on porcine 17 ovarian cells should be interpreted carefully because iron is an essential element but on the 18 other hand it could induce changes in cellular processes. The general objective of this in 19 vitro stud...

Asem, Elikplimi K., Wuxuan Qin, and Stanley G. Rane. Effect of basal lamina of ovarian follicle on Tand L-type Ca21 currents in differentiated granulosa cells. Am J Physiol Endocrinol Metab 282: E184–E196, 2002.—Patch clamp experiments were conducted to study the effects of basal lamina (basement membrane) of chicken ovarian follicle on membrane Ca21 currents in differentiated chicken granulosa...

Leptin, a recently-discovered hormonal product of the obese gene, circulates in the blood at levels paralleling those of fat reserves and regulates satiety and improves reproductive performance if injected into mice lacking circulating leptin. Therefore, we tested the hypothesis that leptin signals metabolic information to the reproductive system by directly affecting granulosa cell function. D...

Activation of the RAS family of small G-proteins is essential for follicle stimulating hormone-induced signaling events and the regulation of target genes in cultured granulosa cells. To analyze the functions of RAS protein in granulosa cells during ovarian follicular development in vivo, we generated conditional knock-in mouse models in which the granulosa cells express a constitutively active...

Gonadotropin-inhibitory hormone (GnIH), an RFamide peptide, has been found to inhibit pituitary LH secretion in avian and mammalian species. The gene encoding a putative receptor for GnIH (GnIHR) was recently identified in the chicken and Japanese quail brain and pituitary gland. GnIHR appears to be a seven-transmembrane protein belonging to a family of G-protein-coupled receptors. In the prese...

We have cloned and sequenced a chicken homolog to the mammalian interleukin-1beta (IL-1beta)-converting enzyme (caspase-1) cDNA and have evaluated caspase-1 mRNA expression in various tissues from the domestic hen, including ovarian follicle granulosa and theca layers. The deduced amino acid (aa) sequence of chicken caspase-1 is 44.9% identical to human caspase-1, and contains an active site pe...

BACKGROUND Lysophosphatidic acid (LPA) regulates reproductive processes in the cow. Ovarian granulosa cells play a pivotal role in follicle growth and development. Nevertheless, the role of LPA in the local regulation of granulosa cell function in different follicle categories in the bovine ovary has not been investigated. METHODS Ovarian follicles were divided into healthy, transitional and ...