Holliday junctions are four-stranded DNA complexes that are formed during recombination and related DNA repair events. Much work has focused on the overall structure and properties of four-way junctions in solution, but we are just now beginning to understand these complexes at the atomic level. The crystal structures of two all-DNA Holliday junctions have been determined recently from the sequ...

This paper forecasts match outcomes in test cricket in play, session by session. Match outcome probabilities at the start of each session are forecast using a sequence of multinomial logistic regression models. These probabilities can assist a team captain or management in considering a certain aggressive or defensive batting strategy for the coming session. We investigate how the outcome proba...

We identify a large coiled-coil protein, Sme4/PaMe4, that is highly conserved among the large group of Sordariales and plays central roles in two temporally and functionally distinct aspects of the fungal sexual cycle: first as a component of the meiotic synaptonemal complex (SC) and then, after disappearing and reappearing, as a component of the spindle pole body (SPB). In both cases, the prot...

Type II topoisomerases are ubiquitous enzymes that control the topology and higher order structures of DNA. Type IIA enzymes have the remarkable property to sense locally the global DNA topology. Although many theoretical models have been proposed, the molecular mechanism of chiral discrimination is still unclear. While experimental studies have established that topoisomerases IIA discriminate ...

This paper describes an objective speech quality assessment method developed for the Hungarian NMT450 mobile telephone system. The method is based on a psychoacoustic front end followed by a cognitive modeling component. Special problems of the NMT system, such as hand-overs, the effects of automatic gain control (AGC) and intrusion of signaling noise are addressed in the cognitive module. Corr...

In this research we focus on the roles of experience and understanding in fostering integrative negotiation performance. We report on two experiments in which we distinguish between understanding opponents’ general priorities among issues versus understanding their speciWc gains for particular oVers. Although experience enhanced integrative performance even in the absence of understanding, we f...