Background: Aldo-keto oxidoreductase (AKR) inhibitors could reverse the resistance of several cancer cells to cis-platin, but their role in remains unclear.Methods: We verified difference AKR1Cs expression by Western blot, RNA sequencing and qRT-PCR. The differences were analyzed inferred. Use Assay NADH NAD+ content verify inference. Docking experience was used affinity between MPA, MCFLA, MLS...

Two NADPH:cytochrome P450 oxidoreductases (CPRs) from parsley (Petroselinum crispum) were cloned, and the complete proteins were expressed and functionally identified in yeast. The two enzymes, designated CPR1 and CPR2, are 80% identical in amino acid sequence with one another and about 75% identical with CPRs from several other plant species. The mRNA accumulation patterns for CPR1 and CPR2 in...