Corresponding author: Woo-Jong Choi, M.D., Ph.D., Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, Pungnap-dong, Songpa-gu, Seoul 138-736, Korea. Tel: 82-2-3010-3868, Fax: 82-2-3010-6790, E-mail: [email protected] This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (ht...

IMPORTANCE This study presents an innovative method for developing a neuromuscular model of obstructive sleep apnea (OSA). OBJECTIVE To establish a new OSA animal model simulating real upper airway conditions during sleep. DESIGN AND SETTING In vivo animal study at an academic tertiary referral center. SUBJECTS A total of 27 New Zealand white male rabbits were used. INTERVENTION Sleep w...

Background: This randomized, double-blinded clinical study was designed to compare the efficacy and safety of three regimens of intravenous (IV) patient-controlled analgesia (PCA) with remifentanil for postoperative analgesia after laparoscopic-assisted vaginal hysterectomy during the first 24 postoperative hours. Methods: Thirty-four patients were randomly allocated into three groups. The firs...

BACKGROUND AND OBJECTIVES Isoflurane is considered a safe inhalational anesthetic. It has a low level of biotransformation, and low hepatic and renal toxicity. In clinical concentrations, it has minimal negative inotropic effect, causes a small reduction in systemic vascular resistance, and, rarely, can cause cardiac arrhythmias. The objective of this report was to present a case of severe hemo...

V opaque media are ubiquitous in nature. While some materials are opaque because they strongly absorb visible light, others, such as foam, white paint, biological tissue and milk, are opaque because photons traveling within them are predominantly scattered rather than absorbed. A vanishingly small number of photons travel straight through such substances. Instead, light is transported through t...

We investigated the amount and distribution of hydrogen peroxide (H(2)O(2)) generated in a solid gelatin sample irradiated by heavy ion (carbon) beam. We irradiated the gelatin sample, which contained a nitroxyl radical (4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl, TEMPOL), with a 290-MeV/nucleon carbon beam (~128 Gy). To verify the distribution of H(2)O(2) generation in the irradiated sampl...

OBJECTIVE Neonates mechanic ventilation weaning has become a major clinical challenge, and constitutes a large portion of neonatal intensive care units workload. The spontaneous breathing trial (SBT), performed immediately before extubation, can provide useful information on the patient's spontaneous breathing ability. This study aimed to assess the SBT effectiveness for extubation success pred...

BACKGROUND AND AIMS Patient's posture change is commonly employed by a colonoscopist to achieve complete examination. We studied whether patient's posture (left-lateral decubitus vs supine) influenced the success rate of ileal intubation. PATIENTS AND METHODS In this prospective open-label randomized study performed in the Endoscopy Suite of a tertiary-care center, all adult outpatients refer...

RATIONALE Critically ill patients are predisposed to oxyhemoglobin desaturation during intubation. OBJECTIVES To find out whether noninvasive ventilation (NIV), as a preoxygenation method, is more effective at reducing arterial oxyhemoglobin desaturation than usual preoxygenation during orotracheal intubation in hypoxemic, critically ill patients. METHODS Prospective randomized study perfor...

In chronic obstructive pulmonary disease (COPD), daily physical activity is reported to be adversely associated with the magnitude of exercise-induced dynamic hyperinflation and peripheral muscle weakness. There is limited evidence whether central hemodynamic, oxygen transport, and peripheral muscle oxygenation capacities also contribute to reduced daily physical activity. Nineteen patients wit...