BACKGROUND Lung cancers develop via multiple genetic and epigenetic changes, including inactivation of tumor suppressor genes. We previously cloned human G protein-coupled receptor family C type 5A (GPRC5A), whose expression is suppressed in some human lung carcinoma cells, and its mouse homolog Gprc5a. METHODS We generated Gprc5a knockout mice by homologous recombination and studied their ph...

Chronic autoimmune thrombocytopenic purpura (ATP) is a common hematologic disorder in which platelet-specific autoantibodies bind to platelets and enhance their destruction by the reticuloendothelial system. While there has been considerable investigation of the humoral immune abnormalities in ATP, little work has been performed on the cellular immunoregulatory aspects of this autoimmune disord...

BACKGROUND Biomechanical and histological properties of osteochondral transplantation have not been extensively examined. HYPOTHESIS Osteochondral grafts have properties similar to native articular cartilage. STUDY DESIGN Controlled laboratory study. METHODS A 2.7 mm (diameter) x 4.0 mm (depth) osteochondral defect was created in 17 New Zealand white rabbit knees. An osteochondral graft, ...

BACKGROUND The epidemic of overweight/obesity affects youth with type 1 diabetes mellitus (T1DM) and their families. In youth with T1DM and their parents, we examined weight status with reported and expected energy intake and with youth hemoglobin A1c (HbA1c). METHODS In 243 youth (48% female, 13 ± 3 years) and their parents (84% female, 45 ± 6 years), we assessed body mass index (BMI), preva...

OBJECTIVE To compare examination time and visual field loss for ptosis fields obtained with manual kinetic (Goldmann) perimetry and automated static (Humphrey) perimetry. METHODS Both eyes of 12 patients with bilateral aponeurogenic ptosis were prospectively examined using Goldmann and Humphrey (ptosis protocol) perimetry with the eyelids ptotic and taped into a normal position. RESULTS Bil...

OBJECTIVE To determine the association between measures of adiposity (body mass index and waist circumference) and risk factors for heart disease, type 2 diabetes, fatty liver disease, and the clustering of risk factors in middle adolescence. DESIGN Cross-sectional study. SETTING Secondary schools in Sydney. PARTICIPANTS Grade 10 students (N = 496; 58.4% boys; mean [SD] age, 15.4 [0.4] ye...

INTRODUCTION Cardiovascular disease is a leading cause of death and health disparities in Mississippi. Identifying populations with poor cardiovascular health may help direct interventions toward those populations disproportionately affected, which may ultimately increase cardiovascular health and decrease prominent disparities. Our objective was to assess racial differences in the prevalence o...

This experiment was designed to determine whether dietary hemoglobin (Hgb) iron (Fe) could 0271-5317/$ – see fro doi:10.1016/j.nutres.2 4 Corresponding a E-mail address: p sustain normal Fe status in growing rats adequate or deficient in copper (Cu). Forty-eight weanling rats were divided into 3 groups, each consisting of 16 animals. One group was fed a diet containing 40 mg Fe/kg as ferrous su...